{"id":329027,"date":"2021-05-11T10:30:00","date_gmt":"2021-05-11T08:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/low-dose-paclitaxel-coating-also-effective-in-balloons\/"},"modified":"2021-05-11T10:30:00","modified_gmt":"2021-05-11T08:30:00","slug":"low-dose-paclitaxel-coating-also-effective-in-balloons","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/low-dose-paclitaxel-coating-also-effective-in-balloons\/","title":{"rendered":"Low-dose paclitaxel coating also effective in balloons"},"content":{"rendered":"<p><strong>Recent two-year results from the COMPARE trial &#8211; the world&#8217;s first prospective, randomized, controlled head-to-head study of two drug-coated balloons &#8211; showed that the one coated with a lower dose of paclitaxel had a similar primary patency rate as a balloon coated with a higher dose.<\/strong><\/p>\n<p> <!--more--> <\/p>\n<p>Direct comparisons of different drug-eluting therapy systems remain rare. Now, interventional therapy with Medtronic&#8217;s Admiral and Pacific In.Pact DCBs has been compared with Boston Scientific&#8217;s Ranger DCB. The former use a high dose of paclitaxel (3.5&nbsp;\u00b5g\/mm\u00b2), while the latter is a low dose system, 2.0&nbsp;\u00b5g\/mm2. 414&nbsp;PAVK patients stratified according to lesion length were studied. The noninferiority of the lower-dose DCB system was examined, and the primary end points were patency and freedom from serious adverse events. Adverse events were procedure-associated death events within 1 month, major amputations, and revascularizations by 12&nbsp;months. All-cause mortality was a secondary end point.<\/p>\n<p>After two years, the Ranger DCB with a significantly lower dose density of paclitaxel continued to have a similar primary patency rate as the IN.PACT DCB with a higher placlitaxel dose. Openness rates were 71.4% for high-dose DCB and 70.6% for low-dose DCB. Overall mortality was low at 2.2% vs. 3.6% at 2 years, and the target lesion revascularization rate also remained at a low level (17.8% for the Ranger DCB vs. 13% for the IN.PACT DCB). The study will continue with a 5-year follow-up.<\/p>\n<p><em>Source:&nbsp;Boston Scientific<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>Further reading:<\/p>\n<ul>\n<li>Steiner S, et al: COMPARE: prospective, randomized, non-inferiority trial of high- vs. low-dose paclitaxel drug-coated balloons for femoropopliteal interventions. Eur Heart J 2020; doi: 10.1093\/eurheartj\/ehaa049<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><em>CARDIOVASC 2021; 20(1): 26<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recent two-year results from the COMPARE trial &#8211; the world&#8217;s first prospective, randomized, controlled head-to-head study of two drug-coated balloons &#8211; showed that the one coated with a lower dose&hellip;<\/p>\n","protected":false},"author":7,"featured_media":105210,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"PAVK","footnotes":""},"category":[11359,11530,11548,11503],"tags":[20496,20501],"powerkit_post_featured":[],"class_list":["post-329027","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cardiology","category-market-medicine","category-rx-en","category-studies","tag-balloons","tag-dcb-en","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-24 23:15:20","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":329051,"slug":"le-revetement-de-paclitaxel-a-faible-dose-est-egalement-efficace-sur-les-ballons","post_title":"Le rev\u00eatement de paclitaxel \u00e0 faible dose est \u00e9galement efficace sur les ballons","href":"https:\/\/medizinonline.com\/fr\/le-revetement-de-paclitaxel-a-faible-dose-est-egalement-efficace-sur-les-ballons\/"},"it_IT":{"locale":"it_IT","id":329060,"slug":"il-rivestimento-di-paclitaxel-a-basso-dosaggio-e-efficace-anche-per-i-palloncini","post_title":"Il rivestimento di paclitaxel a basso dosaggio \u00e8 efficace anche per i palloncini","href":"https:\/\/medizinonline.com\/it\/il-rivestimento-di-paclitaxel-a-basso-dosaggio-e-efficace-anche-per-i-palloncini\/"},"pt_PT":{"locale":"pt_PT","id":329068,"slug":"revestimento-de-paclitaxel-de-baixa-dose-tambem-eficaz-para-baloes","post_title":"Revestimento de paclitaxel de baixa dose tamb\u00e9m eficaz para bal\u00f5es","href":"https:\/\/medizinonline.com\/pt-pt\/revestimento-de-paclitaxel-de-baixa-dose-tambem-eficaz-para-baloes\/"},"es_ES":{"locale":"es_ES","id":329070,"slug":"el-recubrimiento-con-dosis-bajas-de-paclitaxel-tambien-es-eficaz-para-los-balones","post_title":"El recubrimiento con dosis bajas de paclitaxel tambi\u00e9n es eficaz para los balones","href":"https:\/\/medizinonline.com\/es\/el-recubrimiento-con-dosis-bajas-de-paclitaxel-tambien-es-eficaz-para-los-balones\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/329027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=329027"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/329027\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/105210"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=329027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=329027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=329027"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=329027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}