{"id":332263,"date":"2020-12-09T23:00:01","date_gmt":"2020-12-09T22:00:01","guid":{"rendered":"https:\/\/medizinonline.com\/secondary-prevention-with-colchicine-reduces-cardiovascular-risk\/"},"modified":"2020-12-09T23:00:01","modified_gmt":"2020-12-09T22:00:01","slug":"secondary-prevention-with-colchicine-reduces-cardiovascular-risk","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/secondary-prevention-with-colchicine-reduces-cardiovascular-risk\/","title":{"rendered":"Secondary prevention with colchicine reduces cardiovascular risk"},"content":{"rendered":"

Colchicine has been used in medicine as an alkaloid for a long time and exhibits a broad anti-inflammatory effect. Recent study results now show that its use in patients with stable coronary artery disease can significantly reduce cardiovascular risk. <\/strong><\/p>\n

<\/p>\n

Colchicine, a mitotic inhibitor found in autumn crocus, reduced the risk of cardiovascular-related death, myocardial infarction, stroke, or ischemia-related coronary revascularization by nearly one-third in patients with stable coronary artery disease compared with placebo. This was the conclusion reached by scientists in a data analysis of the LoDoCO2 study [1]. The large, double-blind, randomized, placebo-controlled study included patients aged 35 to 82 years with established coronary disease that had been stable for more than 6 months. In the run-in period, all patients were initially treated with 0.5 mg colchicine daily for 30 days. 5522 patients who tolerated and consented to colchicine were subsequently randomized in a 1:1 ratio to colchicine 0.5 mg\/day or placebo in addition to their standard therapy and followed up for a median of 29 months. The primary end point consisted of cardiovascular death, myocardial infarction, stroke, and ischemia-related coronary revascularization. A primary endpoint event occurred in 264 patients (9.6%) in the placebo group and in 187 (6.8%) in the colchicine group. Accordingly, colchicine reduced the relative risk by 31% compared with placebo. The effect started early and increased during the observation period. The results for secondary endpoints also support the use of colchicine.<\/p>\n

Source: ESC Congress 2020<\/em><\/p>\n

 <\/p>\n

\nLiterature:<\/p>\n

    \n
  1. Nidorf SM, Fiolet ATL, Mosterd A, et al: Colchicine in Patients with Chronic Coronary Disease. NEJM 2020. DOI: 10.1056\/NEJMoa2021372.<\/li>\n<\/ol>\n

     <\/p>\n

    CARDIOVASC 2020; 19(3): 36 (published 9\/19\/20, ahead of print).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

    Colchicine has been used in medicine as an alkaloid for a long time and exhibits a broad anti-inflammatory effect. Recent study results now show that its use in patients with…<\/p>\n","protected":false},"author":7,"featured_media":99575,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Coronary heart disease","footnotes":""},"category":[11359,11513,11548,11503],"tags":[],"powerkit_post_featured":[],"class_list":["post-332263","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cardiology","category-congress-reports","category-rx-en","category-studies","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-01 08:23:18","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":332338,"slug":"la-prevention-secondaire-par-la-colchicine-reduit-le-risque-cardiovasculaire","post_title":"La pr\u00e9vention secondaire par la colchicine r\u00e9duit le risque cardiovasculaire","href":"https:\/\/medizinonline.com\/fr\/la-prevention-secondaire-par-la-colchicine-reduit-le-risque-cardiovasculaire\/"},"it_IT":{"locale":"it_IT","id":332471,"slug":"la-prevenzione-secondaria-con-la-colchicina-riduce-il-rischio-cardiovascolare","post_title":"La prevenzione secondaria con la colchicina riduce il rischio cardiovascolare","href":"https:\/\/medizinonline.com\/it\/la-prevenzione-secondaria-con-la-colchicina-riduce-il-rischio-cardiovascolare\/"},"pt_PT":{"locale":"pt_PT","id":332481,"slug":"a-prevencao-secundaria-com-colchicina-reduz-o-risco-cardiovascular","post_title":"A preven\u00e7\u00e3o secund\u00e1ria com colchicina reduz o risco cardiovascular","href":"https:\/\/medizinonline.com\/pt-pt\/a-prevencao-secundaria-com-colchicina-reduz-o-risco-cardiovascular\/"},"es_ES":{"locale":"es_ES","id":332484,"slug":"la-prevencion-secundaria-con-colchicina-reduce-el-riesgo-cardiovascular","post_title":"La prevenci\u00f3n secundaria con colchicina reduce el riesgo cardiovascular","href":"https:\/\/medizinonline.com\/es\/la-prevencion-secundaria-con-colchicina-reduce-el-riesgo-cardiovascular\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/332263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=332263"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/332263\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/99575"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=332263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=332263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=332263"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=332263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}