{"id":334075,"date":"2020-06-17T00:01:00","date_gmt":"2020-06-16T22:01:00","guid":{"rendered":"https:\/\/medizinonline.com\/significant-covid-19-improvement-with-tocilizumab\/"},"modified":"2020-06-17T00:01:00","modified_gmt":"2020-06-16T22:01:00","slug":"significant-covid-19-improvement-with-tocilizumab","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/significant-covid-19-improvement-with-tocilizumab\/","title":{"rendered":"Significant COVID-19 improvement with tocilizumab."},"content":{"rendered":"<p><strong>In patients with COVID-19 pneumonia, an immune-mediated &#8220;cytokine storm&#8221; is thought to lead to acute respiratory failure and death. The CORIMUNO-19 platform was rapidly developed and established to evaluate the efficacy and tolerability of various immunomodulators and other treatments in adult patients with severe COVID-19 infection through a series of multicenter randomized controlled trials. The starting point was March 27, 2020.<\/strong><\/p>\n<p> <!--more--> <\/p>\n<p>The CORIMUNO-TOCI study investigated the effect of tocilizumab, a monoclonal antibody that blocks the interleukin-6 cytokine receptor and is used clinically, particularly in the treatment of rheumatoid arthritis. Patients hospitalized for moderate or severe COVID-19 pneumonia who did not require intensive care on admission were selected.<\/p>\n<p>The primary composite end point was need for ventilation (noninvasive or mechanical) or death on day 14&nbsp;. A total of 129 patients were randomized: 65 to standard of care + tocilizumab and 64 to standard of care alone. A significantly lower proportion of patients achieved the primary outcome in the tocilizumab arm. The results of this study will be submitted for publication in a peer-reviewed journal.<\/p>\n<p>These results should be independently confirmed by additional studies. Given the pandemic context, the investigators and sponsor felt ethically obligated to disclose this information pending peer review and longer follow-up. Additional CORIMUNO studies testing other IL-6 receptor inhibitors and other immunomodulators are currently being analyzed. The CORIMUNO-19 test platform is sponsored and funded by Assistance Publique-H\u00f4pitaux de Paris and supported by Reacting \/ INSERM.<\/p>\n<p>\n<em>Source: H\u00f4pitaux de Paris \/ Paris University Hospitals.<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><em>InFo PNEUMOLOGY &amp; ALLERGOLOGY 2020; 2(2): 4 (published 6\/17\/20, ahead of print).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In patients with COVID-19 pneumonia, an immune-mediated &#8220;cytokine storm&#8221; is thought to lead to acute respiratory failure and death. The CORIMUNO-19 platform was rapidly developed and established to evaluate the&hellip;<\/p>\n","protected":false},"author":7,"featured_media":97446,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"CORIMUNO-TOCI Study  ","footnotes":""},"category":[11406,11500,11455,11548,11503],"tags":[13239,13243],"powerkit_post_featured":[],"class_list":["post-334075","post","type-post","status-publish","format-standard","has-post-thumbnail","category-infectiology","category-news-en","category-pneumology","category-rx-en","category-studies","tag-corona-en","tag-covid-en","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-19 12:42:40","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":334079,"slug":"amelioration-significative-du-covid-19-avec-le-tocilizumab","post_title":"Am\u00e9lioration significative du COVID-19 avec le tocilizumab","href":"https:\/\/medizinonline.com\/fr\/amelioration-significative-du-covid-19-avec-le-tocilizumab\/"},"it_IT":{"locale":"it_IT","id":334081,"slug":"miglioramento-significativo-della-covid-19-con-tocilizumab","post_title":"Miglioramento significativo della COVID-19 con tocilizumab","href":"https:\/\/medizinonline.com\/it\/miglioramento-significativo-della-covid-19-con-tocilizumab\/"},"pt_PT":{"locale":"pt_PT","id":334036,"slug":"melhoria-significativa-da-covid-19-com-tocilizumab","post_title":"Melhoria significativa da COVID-19 com tocilizumab","href":"https:\/\/medizinonline.com\/pt-pt\/melhoria-significativa-da-covid-19-com-tocilizumab\/"},"es_ES":{"locale":"es_ES","id":334046,"slug":"mejora-significativa-de-covid-19-con-tocilizumab","post_title":"Mejora significativa de COVID-19 con tocilizumab","href":"https:\/\/medizinonline.com\/es\/mejora-significativa-de-covid-19-con-tocilizumab\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/334075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=334075"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/334075\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/97446"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=334075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=334075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=334075"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=334075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}