{"id":335614,"date":"2019-09-26T02:00:00","date_gmt":"2019-09-26T00:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/peptide-receptor-blockade-also-effective-and-safe-in-the-long-term\/"},"modified":"2019-09-26T02:00:00","modified_gmt":"2019-09-26T00:00:00","slug":"peptide-receptor-blockade-also-effective-and-safe-in-the-long-term","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/peptide-receptor-blockade-also-effective-and-safe-in-the-long-term\/","title":{"rendered":"Peptide receptor blockade also effective and safe in the long term"},"content":{"rendered":"<p><strong>It is estimated that about 11% of the population suffers from migraine. Effective therapeutic options, especially for prophylaxis, are therefore urgently needed. Study results now also confirm long-term efficacy for erenumab.<\/strong><\/p>\n<p> <!--more--> <\/p>\n<p>The CGRP receptor antibody for migraine prophylaxis erenumab (<sup>Aimovig\u00ae<\/sup>) 140&nbsp;mg reduces both the number of monthly migraine days (MMDs) and the number of monthly days of use of migraine-specific symptomatic medications (MSMDs), according to analyses of the study data. Patients showed rapid improvement in all efficacy parameters at weeks 13-16 and 21-24. Outcomes related to patients&#8217; physical impairment and their ability to participate in daily activities also showed improvement. This long-term efficacy is particularly important for patients who have not previously been able to receive effective preventive therapy.<\/p>\n<h2 id=\"significant-reduction-in-acute-medication\">Significant reduction in acute medication<\/h2>\n<p>The fact that the number of acute migraine medication days can be reduced by half is also underscored by data from the active treatment phase of STRIVE. Here, we evaluated the efficacy and safety of erenumab 70 and 140&nbsp;mg in episodic migraine patients with prior preventive treatment failures. 55% of patients receiving 140&nbsp;mg of the CGRP receptor antibody had at least a 50% reduction in the number of monthly migraine days requiring acute medication. The efficacy could be demonstrated sustainably up to the 52nd week.<br \/>\n&nbsp;<\/p>\n<p><em>Sources:<\/em><\/p>\n<ul>\n<li><em>Media Update, &#8220;Novartis data underpin long-term efficacy of <sup>Aimovig\u00ae<\/sup> where other treatments have failed,&#8221; 07\/01\/2019.<\/em><\/li>\n<li><em>Media Update &#8220;Novartis data show <sup>Aimovig\u00ae<\/sup> cuts acute migraine medication days by half in patients who failed prior preventive therapies,&#8221; 07\/01\/2019.<\/em><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><em>HAUSARZT PRAXIS 2019; 14(8): 48<br \/>\nInFo NEUROLOGY &amp; PSYCHIATRY 2019; 17(5): 36.<\/em><br \/>\n&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is estimated that about 11% of the population suffers from migraine. Effective therapeutic options, especially for prophylaxis, are therefore urgently needed. Study results now also confirm long-term efficacy for&hellip;<\/p>\n","protected":false},"author":7,"featured_media":91041,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Migraine prevention","footnotes":""},"category":[11297,11530,11363,11548,11503],"tags":[13855,13856],"powerkit_post_featured":[],"class_list":["post-335614","post","type-post","status-publish","format-standard","has-post-thumbnail","category-general-internal-medicine","category-market-medicine","category-neurology","category-rx-en","category-studies","tag-headache","tag-migraine","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-30 12:11:52","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":335613,"slug":"blocage-des-recepteurs-de-peptides-efficace-et-sur-meme-a-long-terme","post_title":"Blocage des r\u00e9cepteurs de peptides efficace et s\u00fbr, m\u00eame \u00e0 long terme","href":"https:\/\/medizinonline.com\/fr\/blocage-des-recepteurs-de-peptides-efficace-et-sur-meme-a-long-terme\/"},"it_IT":{"locale":"it_IT","id":335615,"slug":"il-blocco-dei-recettori-peptidici-e-efficace-e-sicuro-anche-a-lungo-termine","post_title":"Il blocco dei recettori peptidici \u00e8 efficace e sicuro anche a lungo termine.","href":"https:\/\/medizinonline.com\/it\/il-blocco-dei-recettori-peptidici-e-efficace-e-sicuro-anche-a-lungo-termine\/"},"pt_PT":{"locale":"pt_PT","id":335626,"slug":"bloqueio-do-receptor-do-peptideo-tambem-eficaz-e-seguro-a-longo-prazo","post_title":"Bloqueio do receptor do pept\u00eddeo tamb\u00e9m eficaz e seguro a longo prazo","href":"https:\/\/medizinonline.com\/pt-pt\/bloqueio-do-receptor-do-peptideo-tambem-eficaz-e-seguro-a-longo-prazo\/"},"es_ES":{"locale":"es_ES","id":335617,"slug":"el-bloqueo-de-los-receptores-peptidicos-tambien-es-eficaz-y-seguro-a-largo-plazo","post_title":"El bloqueo de los receptores pept\u00eddicos tambi\u00e9n es eficaz y seguro a largo plazo","href":"https:\/\/medizinonline.com\/es\/el-bloqueo-de-los-receptores-peptidicos-tambien-es-eficaz-y-seguro-a-largo-plazo\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/335614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=335614"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/335614\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/91041"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=335614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=335614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=335614"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=335614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}