{"id":335940,"date":"2019-07-23T02:00:00","date_gmt":"2019-07-23T00:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/deciphering-cardiotoxicity-using-relevant-biomarkers\/"},"modified":"2019-07-23T02:00:00","modified_gmt":"2019-07-23T00:00:00","slug":"deciphering-cardiotoxicity-using-relevant-biomarkers","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/deciphering-cardiotoxicity-using-relevant-biomarkers\/","title":{"rendered":"Deciphering cardiotoxicity using relevant biomarkers."},"content":{"rendered":"<p><strong>Biomarkers play a major role in cardiovascular disease. In addition to diagnosis and monitoring, they also appear to provide an early indication of cardiovascular side effects in malignancies.<\/strong><\/p>\n<p> <!--more--> <\/p>\n<p>Better understanding and the associated more effective treatment options for malignant diseases are leading to a growing number of long-term survivors. Thus, the importance of early knowledge of potential therapy-associated cardiovascular side effects increases. A meta-analysis further examined the cardiac biomarkers troponin (cTN) and brain natriuretic peptide (BNP\/NT-proBNP) for their effectiveness in detecting therapy-associated cardiotoxicity in cancer treatments.<\/p>\n<p>A total of 5 664 patients from 57 studies were analyzed. The primary end point was defined as a reduction in left ventricular ejection fraction (LVEF) above a predefined threshold. Conventional chemotherapy and HER2 inhibitor therapy were found to be associated with increased troponin (OR: 14.2; 95% CI: 7.5-27.0). Prognostically, this indicated the development of left ventricular dysfunction. The strongest effect was demonstrated in patients receiving high-dose chemotherapy. With a negative predictive value of 94% in predicting cardiotoxicity, troponin was identified as a beneficial marker for screening high-risk patients. However, this finding does not apply to BNP\/NT-proBNP. A pathologically elevated value was not significantly associated with the incidence of left ventricular dysfunction.<\/p>\n<p><em>Source: Michel L, et al: Clin Res Cardiol 2019; 108, Suppl 1. DOI: 10.1007\/s00392-019-01435-9.<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><em>CARDIOVASC 2019; 18(3): 35<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biomarkers play a major role in cardiovascular disease. In addition to diagnosis and monitoring, they also appear to provide an early indication of cardiovascular side effects in malignancies.<\/p>\n","protected":false},"author":7,"featured_media":89926,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Cardiooncology","footnotes":""},"category":[11359,11508,11370,11548],"tags":[13687,28323,28328],"powerkit_post_featured":[],"class_list":["post-335940","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cardiology","category-education","category-oncology","category-rx-en","tag-biomarker-en","tag-cardiooncology","tag-cardiotoxicity","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-13 12:18:32","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":335950,"slug":"decrypter-la-cardiotoxicite-a-laide-de-biomarqueurs-pertinents","post_title":"D\u00e9crypter la cardiotoxicit\u00e9 \u00e0 l'aide de biomarqueurs pertinents","href":"https:\/\/medizinonline.com\/fr\/decrypter-la-cardiotoxicite-a-laide-de-biomarqueurs-pertinents\/"},"it_IT":{"locale":"it_IT","id":335957,"slug":"decifrare-la-cardiotossicita-utilizzando-biomarcatori-rilevanti","post_title":"Decifrare la cardiotossicit\u00e0 utilizzando biomarcatori rilevanti","href":"https:\/\/medizinonline.com\/it\/decifrare-la-cardiotossicita-utilizzando-biomarcatori-rilevanti\/"},"pt_PT":{"locale":"pt_PT","id":335964,"slug":"decifrar-a-cardiotoxicidade-utilizando-biomarcadores-relevantes","post_title":"Decifrar a cardiotoxicidade utilizando biomarcadores relevantes","href":"https:\/\/medizinonline.com\/pt-pt\/decifrar-a-cardiotoxicidade-utilizando-biomarcadores-relevantes\/"},"es_ES":{"locale":"es_ES","id":335930,"slug":"descifrar-la-cardiotoxicidad-utilizando-biomarcadores-relevantes","post_title":"Descifrar la cardiotoxicidad utilizando biomarcadores relevantes","href":"https:\/\/medizinonline.com\/es\/descifrar-la-cardiotoxicidad-utilizando-biomarcadores-relevantes\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/335940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=335940"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/335940\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/89926"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=335940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=335940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=335940"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=335940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}