{"id":336656,"date":"2019-02-22T01:00:00","date_gmt":"2019-02-22T00:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/good-effects-on-exacerbation-rate-possible\/"},"modified":"2019-02-22T01:00:00","modified_gmt":"2019-02-22T00:00:00","slug":"good-effects-on-exacerbation-rate-possible","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/good-effects-on-exacerbation-rate-possible\/","title":{"rendered":"Good effects on exacerbation rate possible"},"content":{"rendered":"

Vitamin D deficiency appears to be associated with an unfavorable prognosis in a wide range of diseases. Conversely, substitution is thought to have a variety of beneficial effects, and it certainly seems to have a positive impact in the context of exacerbation prevention in COPD.<\/strong><\/p>\n

<\/p>\n

The systematic review and meta-analysis [1] pooled patients from four randomized controlled trials (RCT) (n=560) who received oral vitamin D3 vs. placebo. Patients were evaluated for rates of moderate to severe exacerbations.<\/p>\n

The result was presented by Professor Dr. Claus Vogelmeier, Department of Internal Medicine, Focus Pneumology, University Hospital Giessen and Marburg, at the Pneumo-Update in Mainz (D): When evaluating the overall population, the rate ratio for moderate\/severe COPD exacerbations in the intervention group was 0.94. Thus, no relevant effect of substitution was detectable. However, when patients were broken down by their vitamin D levels, a clear signal emerged in the subgroup with baseline low vitamin D levels: protective effects were detectable in participants with baseline measured vitamin D levels <25 nmol\/l (adjusted RR 0.55). In contrast, this effect was not seen with vitamin D levels of at least 25 nmol\/l (adjusted RR 1.04) (Fig. 1)<\/strong>.<\/p>\n

 <\/p>\n

\"\"<\/p>\n

 <\/p>\n

Thus, in the presence of reduced vitamin D levels, substitution may have potentially significant beneficial effects on exacerbation rates. Therefore, it should be considered for the future whether the administration of the drug could also be used as a preventive measure in patients with recurrent exacerbations.<\/p>\n

Conclusion<\/h2>\n
    \n
  • Vitamin D substitution in patients with recurrent exacerbations and low blood levels should be considered.<\/li>\n
  • The therapy is inexpensive and safe.<\/li>\n<\/ul>\n

     <\/p>\n

    Literature:<\/p>\n

      \n
    1. Jolliffe DA, et al: Vitamin D to prevent exacerbations of COPD. Thorax 2019; 74: 337-345.<\/li>\n<\/ol>\n

       <\/p>\n

      InFo PNEUMOLOGY & ALLERGOLOGY 2019; 1(3): 36.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

      Vitamin D deficiency appears to be associated with an unfavorable prognosis in a wide range of diseases. Conversely, substitution is thought to have a variety of beneficial effects, and it…<\/p>\n","protected":false},"author":7,"featured_media":93816,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Vitamin D in COPD","footnotes":""},"category":[11508,11455,11548,11503],"tags":[],"powerkit_post_featured":[],"class_list":["post-336656","post","type-post","status-publish","format-standard","has-post-thumbnail","category-education","category-pneumology","category-rx-en","category-studies","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-15 13:31:22","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":336663,"slug":"bons-effets-possibles-sur-le-taux-dexacerbation","post_title":"Bons effets possibles sur le taux d'exacerbation","href":"https:\/\/medizinonline.com\/fr\/bons-effets-possibles-sur-le-taux-dexacerbation\/"},"it_IT":{"locale":"it_IT","id":336667,"slug":"sono-possibili-buoni-effetti-sul-tasso-di-esacerbazione","post_title":"Sono possibili buoni effetti sul tasso di esacerbazione","href":"https:\/\/medizinonline.com\/it\/sono-possibili-buoni-effetti-sul-tasso-di-esacerbazione\/"},"pt_PT":{"locale":"pt_PT","id":336677,"slug":"possibilidade-de-bons-efeitos-na-taxa-de-exacerbacao","post_title":"Possibilidade de bons efeitos na taxa de exacerba\u00e7\u00e3o","href":"https:\/\/medizinonline.com\/pt-pt\/possibilidade-de-bons-efeitos-na-taxa-de-exacerbacao\/"},"es_ES":{"locale":"es_ES","id":336643,"slug":"posibles-buenos-efectos-sobre-la-tasa-de-exacerbacion","post_title":"Posibles buenos efectos sobre la tasa de exacerbaci\u00f3n","href":"https:\/\/medizinonline.com\/es\/posibles-buenos-efectos-sobre-la-tasa-de-exacerbacion\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/336656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=336656"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/336656\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/93816"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=336656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=336656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=336656"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=336656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}