{"id":339353,"date":"2017-09-22T02:00:00","date_gmt":"2017-09-22T00:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/study-of-association-with-hla-genetic-type\/"},"modified":"2017-09-22T02:00:00","modified_gmt":"2017-09-22T00:00:00","slug":"study-of-association-with-hla-genetic-type","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/study-of-association-with-hla-genetic-type\/","title":{"rendered":"Study of association with HLA genetic type."},"content":{"rendered":"<p><strong>To date, it is unclear whether autoimmune encephalitites caused by LGI-1 or NMDA antibodies have a genetic basis. Therefore, the association with HLA genetic type was investigated in this study.<\/strong><\/p>\n<p><!--more--><\/p>\n<p><strong>Purpose: <\/strong>To date, it is unclear whether autoimmune encephalitides caused by LGI-1 or NMDA antibodies have a genetic basis. Therefore, the association with HLA genetic type was investigated in this study.<\/p>\n<p><strong>Background: <\/strong>Since the description of LGI-1 and NMDA antibody-associated encephalitides, the clinical spectrum has expanded strikingly from the typical clinical presentations (memory impairment, facio-brachial dystonic seizures in LGI-1 AE and psychosis and oromandibular dyskinesias of both NMDAR AE) and now extends well into pediatrics. From the initial &#8220;hummingbird&#8221;, these diseases are now pushing their way into our clinical routine with increasing frequency. The reason why these autoencephalitides develop is largely unknown &#8211; especially the question of a possible genetic predisposition.<\/p>\n<p>PATIENTS <strong>AND METHODS:<\/strong> Patients with autoimmune encephalitis were prospectively collected. In case of existing clinical suspicion with subacute development of memory impairment, altered cognition and behavioral abnormalities, antibodies (LGI-1, NMDAR and still others) were tested and an infectious or paraneoplastic cause was excluded. In cases of confirmed LGI-1 or NMDAR-associated AE, HLA genotyping was also performed. There were two control groups, one with patients with epilepsy and the other with healthy controls. HLA typing was performed in a total of 11 patients with LGI-1 AE and in 17 patients with NMDAR AE.<\/p>\n<p><strong>Results: <\/strong>The DRB1*07:01-DQB1*02:02 HLA haplotype was present in LGI-1 AE in 91% of cases compared with 10-13% in epilepsy patients and healthy controls, respectively. No disproportionate clustering of any HLA subtype was found in NMDAR AE.<\/p>\n<p><strong>Comment: <\/strong>Although these data are from a monocentric relatively small collective from South Korea, it can be said that LGI-1 AE is associated with an HLA subtype and thus has a strong genetic predisposition. This is important for further understanding and research of the disease and counseling of patients. The absence of these HLA types in a patient with LGI-1AE should prompt a search for a paraneoplastic etiology.<\/p>\n<p>&nbsp;<\/p>\n<p><em>InFo NEUROLOGY &amp; PSYCHIATRY 2017; 15(4): 35.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>To date, it is unclear whether autoimmune encephalitites caused by LGI-1 or NMDA antibodies have a genetic basis. Therefore, the association with HLA genetic type was investigated in this study.<\/p>\n","protected":false},"author":7,"featured_media":70279,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Autoimmune encephalitis","footnotes":""},"category":[11396,11363,11323,11548,11503],"tags":[37114,37117],"powerkit_post_featured":[],"class_list":["post-339353","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","category-neurology","category-partner-content-en","category-rx-en","category-studies","tag-atoimmune-encephalitis","tag-hla-genetic-type","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-27 21:40:38","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":339364,"slug":"etude-dassociation-avec-le-type-genetique-hla","post_title":"\u00c9tude d'association avec le type g\u00e9n\u00e9tique HLA","href":"https:\/\/medizinonline.com\/fr\/etude-dassociation-avec-le-type-genetique-hla\/"},"it_IT":{"locale":"it_IT","id":339370,"slug":"studio-sullassociazione-con-il-tipo-genetico-hla","post_title":"Studio sull'associazione con il tipo genetico HLA","href":"https:\/\/medizinonline.com\/it\/studio-sullassociazione-con-il-tipo-genetico-hla\/"},"pt_PT":{"locale":"pt_PT","id":339379,"slug":"estudo-sobre-a-associacao-com-o-tipo-genetico-hla","post_title":"Estudo sobre a associa\u00e7\u00e3o com o tipo gen\u00e9tico HLA","href":"https:\/\/medizinonline.com\/pt-pt\/estudo-sobre-a-associacao-com-o-tipo-genetico-hla\/"},"es_ES":{"locale":"es_ES","id":339385,"slug":"estudio-sobre-la-asociacion-con-el-tipo-genetico-hla","post_title":"Estudio sobre la asociaci\u00f3n con el tipo gen\u00e9tico HLA","href":"https:\/\/medizinonline.com\/es\/estudio-sobre-la-asociacion-con-el-tipo-genetico-hla\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/339353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=339353"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/339353\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/70279"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=339353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=339353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=339353"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=339353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}