{"id":340041,"date":"2017-04-03T02:00:00","date_gmt":"2017-04-03T00:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/high-dose-baclofen-treatment\/"},"modified":"2017-04-03T02:00:00","modified_gmt":"2017-04-03T00:00:00","slug":"high-dose-baclofen-treatment","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/high-dose-baclofen-treatment\/","title":{"rendered":"High-Dose Baclofen Treatment"},"content":{"rendered":"<p><strong><em>Purpose: <\/em>Few medications are approved for the treatment of alcohol dependence. Is drug therapy with baclofen in the high-dose range a suitable alternative?<\/strong><\/p>\n<p> <!--more--> <\/p>\n<p><strong>Background:<\/strong> Initial larger studies showed contrasting results regarding the efficacy of low-dose baclofen (30&nbsp;mg\/d). However, case reports with high-dose baclofen (up to 270&nbsp;mg\/d) suggest a dose-dependent effect. In 2015, the BACLAD study showed an effective effect of high-dose treatment [1]. The aim of a Dutch study was to test the efficacy of low- and high-dose baclofen and the dose-response relationship [2].<\/p>\n<p><strong>PATIENTS AND METHODS: <\/strong>In the double-blind multicenter study, 151 patients were randomized to receive high-dose baclofen (up to 150&nbsp;mg), low-dose baclofen (30&nbsp;mg), or placebo for four months. In the high-dose group, titration of baclofen took place during the first six weeks. The primary endpoint of the study was relapse rate.<\/p>\n<p><strong>Results:<\/strong> Over the complete medication period and in the 10 weeks after the titration phase, there were no differences in relapse rates among the three groups. After the titration phase, 27.5% of patients in the high-dose group, 20% in the low-dose group, and 25% in the placebo group had a relapse. Similar results are found over the full medication period with 50% relapses in the high-dose group, 48.4% in the low-dose group, and 46.8% in the placebo group.<\/p>\n<p><strong>CONCLUSION:<\/strong> Neither low-dose nor high-dose baclofen was shown to be effective. However, only 15% of patients in the high-dose group reached the target dose (mean: 94&nbsp;mg\/d). Compared with the BACLAD study (180&nbsp;mg\/d), this means that the dose achieved is almost half as high. Relapsed patients in the high-dose group achieved a lower dose (84.4&nbsp;mg\/d) than abstinent patients (102.4&nbsp;mg, p=0.02). In contrast, a post-hoc analysis showed no difference between patients receiving a minimum dose of 120 mg\/d and the placebo group.<\/p>\n<p>&nbsp;<\/p>\n<ol>\n<li>Muller, C.A., et al: High-dose baclofen for the treatment of alcohol dependence (BACLAD study): a randomized, placebo-controlled trial. Eur Neuropsychopharmacol, 2015. 25(8): 1167-77.<\/li>\n<li>Beraha, E.M., et al: Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: A multicentre, randomised, double-blind controlled trial. Eur Neuropsychopharmacol, 2016. 26(12): p. 1950-1959.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><em>InFo NEUROLOGY &amp; PSYCHIATRY 2017; 15(2): 24-26.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Purpose: Few medications are approved for the treatment of alcohol dependence. Is drug therapy with baclofen in the high-dose range a suitable alternative?<\/p>\n","protected":false},"author":7,"featured_media":65137,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Alcohol dependence","footnotes":""},"category":[11442,11466,11548,11503],"tags":[22451,33435,39059],"powerkit_post_featured":[],"class_list":["post-340041","post","type-post","status-publish","format-standard","has-post-thumbnail","category-pharmacology-and-toxicology","category-psychiatry-and-psychotherapy","category-rx-en","category-studies","tag-addiction","tag-alcohol-en","tag-baclofen-en","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-20 20:08:38","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":340050,"slug":"traitement-au-baclofene-a-haute-dose","post_title":"Traitement au baclof\u00e8ne \u00e0 haute dose","href":"https:\/\/medizinonline.com\/fr\/traitement-au-baclofene-a-haute-dose\/"},"it_IT":{"locale":"it_IT","id":340057,"slug":"trattamento-con-baclofene-ad-alto-dosaggio","post_title":"Trattamento con baclofene ad alto dosaggio","href":"https:\/\/medizinonline.com\/it\/trattamento-con-baclofene-ad-alto-dosaggio\/"},"pt_PT":{"locale":"pt_PT","id":340065,"slug":"tratamento-de-alta-dose-de-baclofeno","post_title":"Tratamento de alta dose de baclofeno","href":"https:\/\/medizinonline.com\/pt-pt\/tratamento-de-alta-dose-de-baclofeno\/"},"es_ES":{"locale":"es_ES","id":340070,"slug":"tratamiento-con-altas-dosis-de-baclofeno","post_title":"Tratamiento con altas dosis de baclofeno","href":"https:\/\/medizinonline.com\/es\/tratamiento-con-altas-dosis-de-baclofeno\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/340041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=340041"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/340041\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/65137"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=340041"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=340041"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=340041"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=340041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}