{"id":340047,"date":"2017-04-02T02:00:00","date_gmt":"2017-04-02T00:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/major-depression-and-anxiety-symptoms\/"},"modified":"2017-04-02T02:00:00","modified_gmt":"2017-04-02T00:00:00","slug":"major-depression-and-anxiety-symptoms","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/major-depression-and-anxiety-symptoms\/","title":{"rendered":"Major depression and anxiety symptoms"},"content":{"rendered":"<p><strong><em>Background: <\/em>Anxiety disorders are a common comorbidity of depression. A comorbidity of depression and anxiety is more difficult to treat than depression alone.<\/strong><\/p>\n<p> <!--more--> <\/p>\n<p>In September 2013, a new antidepressant (vortioxetine) was approved for the U.S. market for the treatment of major depression in adults. The drug has also been approved and available in Switzerland since August 17,&nbsp;2016. Vortioxetine is a Selective Serotonin Reuptake Inhibitor (SSRI) that acts antagonistically on the 5-HT3, 5-HT7, and 5-HT1D receptors, partialagonistically on 5-HT1B, and agonistically on the 5-HT1A receptors. Vortioxetine modulates various neurotransmitter systems, resulting in an increase in serotonin, norepinephrine, dopamine, acetylcholine, histamine, glutamate, and a reduction in GABA. The aim of the study and meta-analysis was to determine the efficacy, safety, and tolerability of vortioxetine in MDD patients with high anxiety symptoms (baseline Hamilton Anxiety Rating Scale [HAM-A] total score \u226520).<\/p>\n<p><strong>PATIENT AND METHODS: <\/strong>Efficacy was analyzed using a randomized placebo-controlled trial of vortioxetine 5-20&nbsp;mg for depression treatment over a 6- to 8-week period in two different age groups (18-75 years and \u226565 years) separately. Changes in Montgomery Asberg Depression Rating Scale (MADRS) scores, HAM-A total, and HAM-A subscales should be noted. Safety and tolerability were assessed by treatment-emergent adverse events (TEEE).<\/p>\n<p><strong>Results:<\/strong> A total of 1497 patients (48.6%) were treated with vortioxetine and 860 patients (49.1%) with placebo. All patients had a HAM-A \u226520 before treatment. There were significant differences compared with placebo on the HAM-A mental subscale for all doses. The greatest differences compared with placebo were found with doses of 10 and 20&nbsp;mg.<\/p>\n<p>The most common adverse reactions (\u22655.0%) were nausea, gastrointestinal tract discomfort, dizziness, and headache. The incidence of serious adverse events was 1.3% (placebo) and \u22641.3% (vortioxetine).<\/p>\n<p>According to the authors, vortioxetine was effective in reducing anxiety and depressive symptomatology in patient with MDD and severe anxiety symptomatology.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>InFo PSYCHIATRY &amp; NEUROLOGY 2017; 15(2): 24.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background: Anxiety disorders are a common comorbidity of depression. A comorbidity of depression and anxiety is more difficult to treat than depression alone.<\/p>\n","protected":false},"author":7,"featured_media":65128,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Efficacy analysis vortioxetine","footnotes":""},"category":[11442,11466,11548,11503],"tags":[17932,15955,39080,39066,39077,39072],"powerkit_post_featured":[],"class_list":["post-340047","post","type-post","status-publish","format-standard","has-post-thumbnail","category-pharmacology-and-toxicology","category-psychiatry-and-psychotherapy","category-rx-en","category-studies","tag-antidepressants","tag-dopamine","tag-ht1a-en","tag-mdd-en","tag-subscales","tag-vortioxetine","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-23 08:24:57","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":340062,"slug":"depression-majeure-et-symptomes-danxiete","post_title":"D\u00e9pression majeure et sympt\u00f4mes d'anxi\u00e9t\u00e9","href":"https:\/\/medizinonline.com\/fr\/depression-majeure-et-symptomes-danxiete\/"},"it_IT":{"locale":"it_IT","id":340075,"slug":"depressione-maggiore-e-sintomi-di-ansia","post_title":"Depressione maggiore e sintomi di ansia","href":"https:\/\/medizinonline.com\/it\/depressione-maggiore-e-sintomi-di-ansia\/"},"pt_PT":{"locale":"pt_PT","id":340082,"slug":"principais-sintomas-de-depressao-e-ansiedade","post_title":"Principais sintomas de depress\u00e3o e ansiedade","href":"https:\/\/medizinonline.com\/pt-pt\/principais-sintomas-de-depressao-e-ansiedade\/"},"es_ES":{"locale":"es_ES","id":340085,"slug":"principales-sintomas-de-depresion-y-ansiedad","post_title":"Principales s\u00edntomas de depresi\u00f3n y ansiedad","href":"https:\/\/medizinonline.com\/es\/principales-sintomas-de-depresion-y-ansiedad\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/340047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=340047"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/340047\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/65128"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=340047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=340047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=340047"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=340047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}