{"id":344753,"date":"2014-09-12T16:25:56","date_gmt":"2014-09-12T14:25:56","guid":{"rendered":"https:\/\/medizinonline.com\/more-than-one-meningioma\/"},"modified":"2014-09-12T16:25:56","modified_gmt":"2014-09-12T14:25:56","slug":"more-than-one-meningioma","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/more-than-one-meningioma\/","title":{"rendered":"More than one meningioma?"},"content":{"rendered":"

A case presentation impressively demonstrated that other tumors can metastasize within a meningioma. So you have to look closely at what it is when you come across a meningioma.<\/strong><\/p>\n

<\/p>\n

(ag)<\/em> An astonishing case was recently presented in the Journal of Clinical Endocrinology & Metabolism [1]: A 60-year-old woman with progressive, iodine-refractory thyroid carcinoma with skeletal and pulmonary metastases developed right-sided ataxia. Intracranial metastasis was suspected. Scintigraphy after the sixth run of I-131(radioiodine) therapy had identified a new lesion of the posterior cranial fossa. Magnetic resonance imaging of the brain showed a dura-resident mass over 20 mm in diameter in the posterior fossa, suggestive of meningioma.<\/p>\n

With a tentative diagnosis of metastasis to the posterior fossa, treatment changed from prednisolone to dexamethasone 4 mg twice daily. This medication was maintained until metastasectomy one month later.<\/p>\n

Histopathology revealed a WHO grade I meningioma. Interestingly, this meningioma contained a metastatic, poorly differentiated thyroid carcinoma. Although the patient had a symptomatic response to metastasectomy and external beam radiotherapy, she died a year later from complications of cauda equina syndrome.<\/p>\n

A tumor within a tumor<\/h2>\n

Undiagnosed thyroid cancer may present as intracranial metastases mimicking meningioma [2]. Thus, it is important to more closely examine a lesion that appears benign at first glance. Meningioma is the most common intracranial tumor that harbors metastases (often from the lung and breast) [3].<\/p>\n

Thyroid cancer and meningiomas are similar in biological, metabolic, molecular, and hormonal factors. However, the exact mechanism behind tumor-to-tumor metastases is unknown. Meningiomas themselves (without thyroid cancer) may show iodine affinity on scintigraphy due to edema and high vascularity.<\/p>\n

What is the finding?<\/h2>\n

The authors note that this is the first published case of poorly differentiated thyroid carcinoma metastasizing inside an intracranial meningioma that developed from a multifocal mixed thyroid cancer.<\/p>\n

Although meningiomas can physiologically concentrate I-131, their case, according to the authors, shows that the exclusion of metastases from a potentially more dangerous primary tumor in an apparently benign lesion is of great importance.<\/p>\n

Literature:<\/strong><\/p>\n

    \n
  1. Ling M, et al: Tumor within Another Tumor: An Unusual Case of Metastatic Poorly Differentiated Thyroid Carcinoma within an Intracranial Meningioma. J Clin Endocrinol Metab 2014, doi: 10.1210\/jc.2014-1310.<\/li>\n
  2. Portocarrero-Ortiz L, et al: Thyroid follicular carcinoma presenting as skull and dural metastasis mimicking a meningioma: a case report. J Neurooncol 2009; 95: 281-284.<\/li>\n
  3. Moody P, et al: Tumor to tumor metastasis: pathology and neuroimaging considerations. J Clin Exp Pathol 2012; 5(4): 367-373.<\/li>\n<\/ol>\n

    InFo Oncology & Hematology 2014; 2(7): 3-4.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

    A case presentation impressively demonstrated that other tumors can metastasize within a meningioma. So you have to look closely at what it is when you come across a meningioma.<\/p>\n","protected":false},"author":7,"featured_media":46434,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Remarkable casuistry","footnotes":""},"category":[11500,11370,11548],"tags":[13365,35538,51213,11555,24558],"powerkit_post_featured":[],"class_list":["post-344753","post","type-post","status-publish","format-standard","has-post-thumbnail","category-news-en","category-oncology","category-rx-en","tag-casuistry","tag-meningioma","tag-metastasis-en","tag-thyroid-gland","tag-tumor-en","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-16 09:10:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":344706,"slug":"plus-dun-meningiome","post_title":"Plus d'un m\u00e9ningiome ?","href":"https:\/\/medizinonline.com\/fr\/plus-dun-meningiome\/"},"it_IT":{"locale":"it_IT","id":344717,"slug":"piu-di-un-meningioma","post_title":"Pi\u00f9 di un meningioma?","href":"https:\/\/medizinonline.com\/it\/piu-di-un-meningioma\/"},"pt_PT":{"locale":"pt_PT","id":344729,"slug":"mais-do-que-um-meningioma","post_title":"Mais do que um meningioma?","href":"https:\/\/medizinonline.com\/pt-pt\/mais-do-que-um-meningioma\/"},"es_ES":{"locale":"es_ES","id":344737,"slug":"mas-de-un-meningioma","post_title":"\u00bfM\u00e1s de un meningioma?","href":"https:\/\/medizinonline.com\/es\/mas-de-un-meningioma\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/344753","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=344753"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/344753\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/46434"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=344753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=344753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=344753"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=344753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}