{"id":356922,"date":"2023-05-20T14:00:00","date_gmt":"2023-05-20T12:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=356922"},"modified":"2023-04-27T21:50:13","modified_gmt":"2023-04-27T19:50:13","slug":"study-compares-risk-of-hospital-mortality","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/study-compares-risk-of-hospital-mortality\/","title":{"rendered":"Study compares risk of hospital mortality"},"content":{"rendered":"\n

In a representative cohort study with data from more than 5000 hospitalized patients in Switzerland, the Corona variant Omicron was associated with a 1.5-fold increased risk of mortality compared with influenza A or B. The results of the study were published in JAMA Network Open<\/em> in February 2023.<\/strong><\/p>\n\n\n\n

The cohort study database was obtained from national Covid 19 and influenza registries in Switzerland. A total of 5212 hospitalized persons over 18 years of age in 15 Swiss hospitals were included [1]. Covid sufferer data (n=3066) were collected between 01\/15\/2012 and 03\/15\/2012. During this period, the Omikron variant (B.1.1.529) was predominant in Switzerland, accounting for over 95% of all covid cases [2]. Omicron was classified as a variant virus of concern by the World Health Organization (WHO) on November 26, 2021 [3]. Although Omikron poses a lower risk of hospitalization and mortality than the delta variant, its transmission rate is higher than that of earlier virus variants [1,4]. <\/p>\n\n

Data on those with influenza (n=2146) were collected during the 2018\/19, 2020\/21, and 2021\/22 influenza seasons. In each case, the circulating subtypes of seasonal influenza were determined as part of the Federal Office of Public Health’s Sentinella reporting system. From 2018 to 2022, influenza A was predominant, while influenza B was in the minority [5]. The proportion of over-65s vaccinated against seasonal influenza varied between 28-38% in Switzerland from 2018 to 2022 [5]. <\/p>\n\n

Results of the cohort study at a glance <\/h3>\n\n

At baseline, those affected by omicron were 71 years old on average; among those with influenza, the average age was 74 years. BMI was 25.5 and 25.3 in the two groups, respectively. Comorbidities** were present in 19% of the Omikron group and 22.2% of those with influenza. The primary and secondary endpoints of the study were defined as in-hospital mortality and ICU admission. Of those with omicron, 214 patients (7.0%) died during hospitalization, compared with 95 patients (4.4%) in the influenza group (p<0.001) (Table 1<\/strong> ) [1]. The need for ICU admission was similar in both groups: 8.6% patients with SARS-CoV-2 omicron variant and 8.3% with influenza (p=0.79) [1]. The length of stay in the ICU also did not differ greatly. Cox regression (cause-specific and Fine Gray models) was used to account for time dependence and competing events. <\/p>\n\n

** Diabetes, cardiovascular disease (CVD), chron. Renal insufficiency (CKD), chronic. Diseases of the lungs or liver, chronic. neurological problem, chron. hematological disease<\/em><\/p>\n\n

\u00a0<\/p>\n

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\"\"<\/a><\/figure>\n<\/div>\n

In summary, in the present cohort study, hospital mortality was found to be significantly higher in those with omicron compared with influenza patients in the sample studied [1]. This is despite increasing immunity in the population and better therapeutic strategies [6]. <\/p>\n\n

Source: Pfizer<\/em><\/p>\n\n

Literature: <\/p>\n\n

    \n
  1. Portmann L, et al; CH-SUR study group. Hospital Outcomes of Community-Acquired SARS-CoV-2 Omicron Variant Infection Compared With Influenza Infection in Switzerland. JAMA Netw Open. 2023 Feb 1; 6(2): e2255599.<\/li>\n\n\n\n
  2. FOPH: COVID-19 Switzerland. Updated March 20, 2022. www.covid19.admin.ch\/de\/epidemiologic\/virus-variants,<\/a> Accessed March 20, 2022.<\/li>\n\n\n\n
  3. WHO: Classification of Omicron (B.1.1.529): SARS-CoV-2 variant of concern. www.who.int\/news\/item\/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern<\/a>, Accessed July 20, 2022<\/li>\n\n\n\n
  4. Davies NG, et al; CMMID COVID-19 Working Group; COVID-19 Genomics UK (COG-UK) Consortium. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science 2021; 372(6538):eabg3055.<\/li>\n\n\n\n
  5. BAG: Seasonal Influenza – Situation Report Switzerland. Updated December 15, 2022. www.bag.admin.ch\/bag\/de\/home\/krankheiten\/ausbrueche-epidemien-pandemien\/aktuelle-ausbrueche-epidemien\/saisonale-grippe—lagebericht-schweiz.html,<\/a> Accessed January 13, 2023.<\/li>\n\n\n\n
  6. “Omicron vs influenza: study compares hospital mortality,” University of Lucerne, Feb. 16, 2023.<\/li>\n<\/ol>\n\n

    <\/p>\n\n

    HAUSARZT PRAXIS 2023; 18(4): 32<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

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