{"id":370348,"date":"2024-01-01T14:00:00","date_gmt":"2024-01-01T13:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=370348"},"modified":"2024-01-01T14:28:53","modified_gmt":"2024-01-01T13:28:53","slug":"lavender-oil-preparation-and-z-drugs-in-retrospective-comparison","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/lavender-oil-preparation-and-z-drugs-in-retrospective-comparison\/","title":{"rendered":"Lavender oil preparation and “Z-drugs” in retrospective comparison"},"content":{"rendered":"\n

From a retrospective cohort study published in 2023 by Kr\u00fcgeret al. shows that patients undergoing GP treatment for sleep disorders were less likely to require follow-up consultations when prescribed a lavender oil-based phytotherapeutic medicine than when prescribed benzodiazepine receptor agonists from the “Z-drugs” group. Patients with anxiety symptoms in addition to sleep disorders can particularly benefit from the well-tolerated phytotherapeutic agent with anxiolytic effects. <\/strong><\/p>\n\n\n\n

GPs are usually the first port of call for sufferers of sleep disorders (box) <\/strong>. The causes of sleep disorders can be very different [11]. It is not uncommon for insomnia to be associated with mental illnesses such as depression or generalized anxiety disorder (GAD) [11]. If non-pharmacological measures do not lead to an improvement in sleep disorders, pharmacotherapeutic treatment should be considered. The “Z-drugs” zolpidem and zopiclone, which belong to the benzodiazepine receptor agonists, are classified as effective sleep-promoting drugs in the current guideline for short-term use (3-4 weeks) [1,10]. Due to the risks of side effects, however, no recommendation is made for long-term treatment. Phytotherapeutics are also mentioned in the guideline. The proprietary lavender oil Silexan\u00ae<\/sup> (WS\u00ae<\/sup> 1265) is obtained by steam distillation from the inflorescences of true lavender (Lavandula angustifolia) and complies with the specifications of the European Pharmacopoeia [4]. Several studies confirm the placebo superiority of Silexan\u00ae<\/sup> in subsyndromal anxiety disorders or GAD [5\u20137]. Seifritz et al. have also shown that Silexan\u00ae<\/sup> has sleep-promoting effects in patients with anxiety disorders [8]. In a retrospective cohort study, Kr\u00fcger et al. investigated the question of how the prescription of Silexan\u00ae<\/sup> vs. “Z-drugs” is associated with the use of GP follow-up consultations [9]. <\/p>\n\n

Sleep disorders, including insomnia, parasomnia, hypersomnolence and sleep-related breathing disorders, are among the most common diagnoses in everyday clinical practice [1,2]. In ICD-10, sleep disorders are assigned to codes G47-F51 [3]. The current S3 guideline recommends offering drug therapy for sleep disorders in patients for whom cognitive-behavioral therapy measures and associated lifestyle changes are not sufficient [10]. In addition to synthetic active ingredients, phytotherapeutic substances with a sleep-promoting effect are also available. <\/td><\/tr><\/tbody><\/table><\/figure>\n\n

In total, data from over 95,000 patients was analyzed <\/h3>\n\n

The analysis included data from patients with sleep disorders who were prescribed Silexan\u00ae<\/sup> (n=5204) or “Z-Drugs” (n=90 526) [9]. Patients who received Silexan\u00ae<\/sup> were on average younger (48.7 vs. 61.5 years) and more often female (66.4% vs. 59.6%) than patients who were treated with “Z-drugs”. The latter were slightly less likely to have a depressive disorder (18.4% vs. 21.7%), an anxiety disorder (5.5% vs. 11.3%) or a stress-related adjustment disorder (8.0% vs. 13.2%) than the Silexan\u00ae<\/sup> patients. In 15.6% of patients treated with Silexan\u00ae<\/sup> and 28.6% of patients treated with “Z-Drugs”, a further consultation with a GP was required within 15 to 365 days due to sleep disorders. Looking at the results of the multivariate logistic regression model, a prescription of Silexan\u00ae<\/sup> was associated with a 44% lower probability of needing a follow-up consultation for sleep disorders within 15-365 days compared to “Z-drugs” across the entire data set (OR: 0.56; 95% CI: 0.51-0.60). Broken down by age group, the corresponding ORs were in the range 0.48-0.65 (Table 1)<\/strong>.<\/p>\n

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Literature:<\/p>\n\n

    \n
  1. Karna B, Sankari A, Tatikonda G: Sleep Disorder. StatPearls [Internet], StatPearls Publishing; Treasure Island, FL, USA: 2022. <\/li>\n\n\n\n
  2. R\u00e9mi J, et al.: Sleep-Related Disorders in Neurology and Psychiatry. Dtsch Arztebl Int 2019; 116: 681\u2013688.<\/li>\n\n\n\n
  3. International Classification of Diseases: ICD-10-GM-2023, www.icd-code.de,<\/a>(last accessed 02.11.2023) <\/li>\n\n\n\n
  4. Arzneimittelinformation, www.swissmedicinfo.ch<\/a>, (letzter Abruf 02.11.2023)<\/li>\n\n\n\n
  5. M\u00f6ller HJ, et al.: Efficacy of Silexan in subthreshold anxiety: Meta-analysis of randomised, placebo-controlled trials. Eur Arch Psychiatry Clin Neurosci 2019; 269: 183\u2013193.<\/li>\n\n\n\n
  6. Yap WS, et al.: Efficacy and safety of lavender essential oil (Silexan) capsules among patients suffering from anxiety disorders: A network meta-analysis. Sci Rep 2019; 9: 18042. <\/li>\n\n\n\n
  7. Kasper S, et al.: Silexan in anxiety disorders: Clinical data and pharmacological background. World J Biol Psychiatry 2018; 19: 412\u2013420.<\/li>\n\n\n\n
  8. Seifritz E, Schl\u00e4fke S, Holsboer-Trachsler E: Beneficial effects of Silexan on sleep are mediated by its anxiolytic effect. J Psychiatry Res 2019; 115: 69. <\/li>\n\n\n\n
  9. Kr\u00fcger T, Becker EM, Kostev K: Prescription of Silexan Is Associated with Less Frequent General Practitioner Repeat Consultations Due to Disturbed Sleep Compared to Benzodiazepine Receptor Agonists: A Retrospective Database Analysis. Healthcare (Basel). 2022 Dec 27; 11(1): 77.<\/li>\n\n\n\n
  10. Riemann D, et al.: S3-Leitlinie Nicht erholsamer Schlaf\/Schlafst\u00f6rungen. Somnologie 2017; 21: 2\u201344. <\/li>\n\n\n\n
  11. Carbone EA, et al.: Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance. Int J Environ Res Public Health 2023 Mar 1; 20(5): 4431.<\/li>\n<\/ol>\n\n

    <\/p>\n\n

    HAUSARZT PRAXIS 2023; 18(11): 41<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

    From a retrospective cohort study published in 2023 by Kr\u00fcgeret al. shows that patients undergoing GP treatment for sleep disorders were less likely to require follow-up consultations when prescribed a…<\/p>\n","protected":false},"author":7,"featured_media":258823,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Treatment of sleep disorders ","footnotes":""},"category":[11297,11447,11466,11548,11503],"tags":[72551,72549,72548,72547,72552,72554,72550,72545,18664,72553,72543],"powerkit_post_featured":[],"class_list":["post-370348","post","type-post","status-publish","format-standard","has-post-thumbnail","category-general-internal-medicine","category-pharmaceutical-medicine","category-psychiatry-and-psychotherapy","category-rx-en","category-studies","tag-anxiety-symptoms-en","tag-anxiolytic","tag-follow-up-consultations","tag-krueger-et-al-en","tag-lavender-oil-en","tag-phytotherapeutic-agent","tag-phytotherapeutic-medicinal-product","tag-retrospective-cohort-study","tag-sleep-disorders","tag-well-tolerated","tag-z-drugs-en","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-14 03:32:34","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":370353,"slug":"comparaison-retrospective-entre-une-preparation-a-base-dhuile-de-lavande-et-des-z-drugs","post_title":"Comparaison r\u00e9trospective entre une pr\u00e9paration \u00e0 base d'huile de lavande et des \"Z-drugs\".","href":"https:\/\/medizinonline.com\/fr\/comparaison-retrospective-entre-une-preparation-a-base-dhuile-de-lavande-et-des-z-drugs\/"},"it_IT":{"locale":"it_IT","id":370360,"slug":"preparazione-allolio-di-lavanda-e-farmaci-z-in-un-confronto-retrospettivo","post_title":"Preparazione all'olio di lavanda e \"farmaci Z\" in un confronto retrospettivo","href":"https:\/\/medizinonline.com\/it\/preparazione-allolio-di-lavanda-e-farmaci-z-in-un-confronto-retrospettivo\/"},"pt_PT":{"locale":"pt_PT","id":370366,"slug":"preparacao-de-oleo-de-lavanda-e-z-drugs-em-comparacao-retrospetiva","post_title":"Prepara\u00e7\u00e3o de \u00f3leo de lavanda e \"Z-Drugs\" em compara\u00e7\u00e3o retrospetiva","href":"https:\/\/medizinonline.com\/pt-pt\/preparacao-de-oleo-de-lavanda-e-z-drugs-em-comparacao-retrospetiva\/"},"es_ES":{"locale":"es_ES","id":370340,"slug":"el-preparado-de-aceite-de-lavanda-y-los-medicamentos-z-en-comparacion-retrospectiva","post_title":"El preparado de aceite de lavanda y los \"medicamentos Z\" en comparaci\u00f3n retrospectiva","href":"https:\/\/medizinonline.com\/es\/el-preparado-de-aceite-de-lavanda-y-los-medicamentos-z-en-comparacion-retrospectiva\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/370348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=370348"}],"version-history":[{"count":3,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/370348\/revisions"}],"predecessor-version":[{"id":373380,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/370348\/revisions\/373380"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/258823"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=370348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=370348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=370348"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=370348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}