{"id":372530,"date":"2024-01-19T14:00:00","date_gmt":"2024-01-19T13:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=372530"},"modified":"2023-12-17T16:42:59","modified_gmt":"2023-12-17T15:42:59","slug":"children-of-primary-school-age-also-benefit-from-the-calming-effects","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/children-of-primary-school-age-also-benefit-from-the-calming-effects\/","title":{"rendered":"Children of primary school age also benefit from the calming effects"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Valerian <em>(Valeriana officinalis L.)<\/em> and lemon balm <em>(Melissa officinalis L.) <\/em>have synergistic effects when used in combination. In an observational study of over 900 schoolchildren, restlessness and sleep disorders were reduced and in a further study of over 150 children, concentration disorders, hyperactivity and impulsivity improved. The tolerability of the herbal preparation was generally very good, with only a few side effects occurring.  <\/strong><\/p>\n\n<!--more-->\n\n<p class=\"wp-block-paragraph\">Attention problems, hyperactivity and impulsivity in children cause far-reaching psychosocial difficulties, particularly in the family and at school [1\u20133]. In addition to schoolchildren who have an ADD\/ADHD diagnosis according to DSM-IV or ICD-10, there are also a number who exhibit subsyndromic symptoms [4\u20136]. Phytotherapeutics are well accepted by both parents and children and are generally very well tolerated [7,8].  <\/p>\n\n<p class=\"wp-block-paragraph\">Valerian<em> (V. officinalis L.)<\/em> as monotherapy or in combination with other herbal medicines has been shown to improve sleep disorders in adults and children [9,10]. Lemon balm <em>(M. officinalis L.)<\/em> promotes relaxation and helps to fall asleep, and there is also evidence of improved attention in young adults [11]. <sup>Dormiplant\u00ae<\/sup> (<sup>WS\u00ae<\/sup> <sup>1303\/WS\u00ae<\/sup> 1014, Schwabe Pharma AG) is a herbal medicine based on valerian and lemon balm [12] <strong>(box) <\/strong>.  <\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-background\" style=\"background-color:#0792e34d\"><tbody><tr><td>One film-coated tablet of <sup>Dormiplant\u00ae<\/sup> contains ethanolic dry extracts of valerian 160 mg (3-6:1) and lemon balm 80 mg (4-6:1) [12]. In Switzerland, this herbal medicine is approved for children from the age of 6. Studies show that <sup>Dormiplant\u00ae<\/sup> is effective and well tolerated not only in adults but also in children. Melissa <sup>WS\u00ae<\/sup> 1303 causes a presynaptic inhibition of GABA transaminase and valerian <sup>WS\u00ae<\/sup> 1014 has a postsynaptic GABA A as well as an adenosinergic effect [12]. The complementary combination of lemon balm and valerian has a calming and sleep-promoting effect [12].  <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<h3 id=\"hyperactive-children-became-calmer-and-more-focused\" class=\"wp-block-heading\">Hyperactive children became calmer and more focused  <\/h3>\n\n<p class=\"wp-block-paragraph\">A secondary analysis published in 2020 by Shinjyo et al. [13] on the effects of valerian root extracts as a mono- or combination preparation for sleep disorders and associated symptoms also included the two studies described below [1,2]. Both were observational studies. As a result, the combined use of dry extracts of valerian and lemon balm in children of primary school age proved to have a positive effect on hyperactivity, concentration and sleep disorders.  <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>Gromball et al. 2014  <\/strong>[2,13]In restless primary school children with concentration problems and impulsivity, a 7-week treatment with <sup>WS\u00ae<\/sup> 1014 and <sup>WS\u00ae<\/sup> 1303 proved to be a useful addition to counseling and education.  <\/p>\n\n<ul class=\"wp-block-list\">\n<li><em>Methods:<\/em> 169 primary school children who suffered from hyperactivity and concentration difficulties but did not meet the ADHD criteria were treated by 27 pediatricians in private practice over a period of 7 weeks with a daily dose of 640 mg valerian root extract <sup>WS\u00ae<\/sup> 1014 and 320 mg lemon balm extract <sup>WS\u00ae<\/sup> 1303. The outcome parameters assessed by pediatricians and parents at baseline and at weeks 2 and 7 using standardized questionnaires were concentration problems, hyperactivity, impulsivity, impaired social behavior, difficulty falling asleep and morning tiredness.  <\/li>\n\n\n\n<li><em>Results:<\/em> The evaluations of the parameters assessed by the doctors show that the proportion of children with severely\/very severely impaired ability to concentrate fell from 75% to 14%, with regard to hyperactivity the proportion fell from 61% to 13% and with impulsivity from 59% to 22%. The social behavior, sleep and symptom burden assessed by the parents showed highly significant improvements. Mild, temporary side effects were only observed in two of the children, although a causal relationship with the drug was considered unlikely.  <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>M\u00fcller&amp; Klement 2006<\/strong> [1,13]: The use of a valerian-lemon balm preparation in children under 12 years of age was shown to alleviate restlessness and sleep disorders in this study.  <\/p>\n\n<ul class=\"wp-block-list\">\n<li><em>Methods<\/em>: In an open, multicenter study, the efficacy and tolerability of a combination preparation of <em>V. officinalis<\/em> and <em>M. officinalis<\/em> was investigated in 918 children under 12 years of age (average age: 8.3 years) who suffered from restlessness and insomnia. The dosage was individually adjusted by the investigators, with a maximum of 2\u00d72 tablets\/day (mean: 3.5 tablets\/day) being prescribed for 4 \u00b1 1 weeks (average 31.9 days). The severity or improvement of symptoms was assessed by investigators and parents.  <\/li>\n\n\n\n<li><em>Results:<\/em> Sleep disturbances and restlessness were reduced from moderate\/severe to mild or none in most patients. Specifically, 80.9% of patients with dyssomnia and 70.4% of patients with restlessness showed a significant improvement. For the other symptoms listed, the average overall improvement was 37.8%. The effectiveness of the treatment was rated as very good or good (60.5% and 67.7%) by both the parents and the investigators. Tolerability proved to be good or very good in 96.7% of patients; there were no adverse treatment-related events.  <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n<p class=\"wp-block-paragraph\">Literature:  <\/p>\n\n<ol class=\"wp-block-list\">\n<li>M\u00fcller S, Klement S: Phytomedicine 2006; 13(6): 383-387.<\/li>\n\n\n\n<li>Gromball J, et al: Phytomedicine 2014; 21(8-9): 1098-1103.<\/li>\n\n\n\n<li>Storeb\u00f8 OJ, et al: Cochrane Database Syst Rev 2011; 7: CD008223<\/li>\n\n\n\n<li>Sass HU, et al: Diagnostic and Statistical Manual of Mental Disorders: Text revision &#8211; DSM-IV-TR, 2003. hogrefe: G\u00f6ttingen. ISBN 3-8017-1660-0.<\/li>\n\n\n\n<li>American Psychiatric Association: Diagnostic and statistical manual of mental disorders (<sup>4th<\/sup> ed., text rev.), 2000, Washington, DC.<\/li>\n\n\n\n<li>ICD-10-GM &#8211; International Statistical Classification of Diseases and Related Health Problems, 10th Revision, German Modification, <a href=\"http:\/\/www.bfs.admin.ch\/bfs\/de\/home\/statistiken\/gesundheit\/nomenklaturen\/medkk\/instrumente-medizinische-kodierung.html\" target=\"_blank\" rel=\"noopener\">www.bfs.admin.ch\/bfs\/de\/home\/statistiken\/gesundheit\/nomenklaturen\/medkk\/instrumente-medizinische-kodierung.html,<\/a>(last accessed 07.12.2023).<\/li>\n\n\n\n<li>Kraft K: Phytopharmaceuticals in children &#8211; indications, possibilities, limits. Pediatric Practice 2008; 79: 282-289.<\/li>\n\n\n\n<li>Larzelere MM, Campbell JS, Robertson M: Prim Care 2010; 37: 213-236.<\/li>\n\n\n\n<li>Fern\u00e1ndez-San-Mart\u00edn MI, et al: Sleep Med 2010; 11: 505-511.<\/li>\n\n\n\n<li>Francis AJ, Dempster RJ: Phytomedicine 2002; 9: 273-279.<\/li>\n\n\n\n<li>Kennedy DO, et al: Pharmacol Biochem Behav 2022; 72: 953-964.<\/li>\n\n\n\n<li>Swissmedic: Medicinal product information, <a href=\"http:\/\/www.swissmedicinfo.ch\" target=\"_blank\" rel=\"noopener\">www.swissmedicinfo.ch,<\/a>(07.12.2023)  <\/li>\n\n\n\n<li>Shinjyo N, Waddell G, Green J: J Evid Based Integr Med 2020 Jan-Dec; 25: 2515690X20967323.<\/li>\n<\/ol>\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n<p class=\"has-small-font-size wp-block-paragraph\"><em>GP PRACTICE 2023: 18(12): 40<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Valerian (Valeriana officinalis L.) and lemon balm (Melissa officinalis L.) have synergistic effects when used in combination. In an observational study of over 900 schoolchildren, restlessness and sleep disorders were&hellip;<\/p>\n","protected":false},"author":7,"featured_media":372533,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Combination preparation of valerian and lemon balm","footnotes":""},"category":[11437,11447,11466,11548,11503],"tags":[17302,73605,73600,23567,25867,73602,73589,12560,73592,73595,70949,18664,73598,12556,73591],"powerkit_post_featured":[],"class_list":["post-372530","post","type-post","status-publish","format-standard","has-post-thumbnail","category-pediatrics","category-pharmaceutical-medicine","category-psychiatry-and-psychotherapy","category-rx-en","category-studies","tag-adhd-en","tag-ads-en","tag-concentration-disorders","tag-dormiplant-en","tag-hyperactivity","tag-impulsiveness","tag-lemon-balm","tag-melissa-en","tag-melissa-officinalis-l-en","tag-mueller-klement-en","tag-observational-study","tag-sleep-disorders","tag-unrest","tag-valerian","tag-valeriana-officinalis-l-en","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-19 16:30:52","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":372537,"slug":"les-enfants-en-age-daller-a-lecole-primaire-beneficient-egalement-de-ses-effets-apaisants","post_title":"Les enfants en \u00e2ge d'aller \u00e0 l'\u00e9cole primaire b\u00e9n\u00e9ficient \u00e9galement de ses effets apaisants","href":"https:\/\/medizinonline.com\/fr\/les-enfants-en-age-daller-a-lecole-primaire-beneficient-egalement-de-ses-effets-apaisants\/"},"it_IT":{"locale":"it_IT","id":372546,"slug":"anche-i-bambini-in-eta-da-scuola-primaria-beneficiano-degli-effetti-calmanti","post_title":"Anche i bambini in et\u00e0 da scuola primaria beneficiano degli effetti calmanti","href":"https:\/\/medizinonline.com\/it\/anche-i-bambini-in-eta-da-scuola-primaria-beneficiano-degli-effetti-calmanti\/"},"pt_PT":{"locale":"pt_PT","id":372554,"slug":"as-criancas-em-idade-escolar-primaria-tambem-beneficiam-dos-efeitos-calmantes","post_title":"As crian\u00e7as em idade escolar prim\u00e1ria tamb\u00e9m beneficiam dos efeitos calmantes","href":"https:\/\/medizinonline.com\/pt-pt\/as-criancas-em-idade-escolar-primaria-tambem-beneficiam-dos-efeitos-calmantes\/"},"es_ES":{"locale":"es_ES","id":372577,"slug":"los-ninos-en-edad-escolar-primaria-tambien-se-benefician-de-los-efectos-calmantes","post_title":"Los ni\u00f1os en edad escolar primaria tambi\u00e9n se benefician de los efectos calmantes","href":"https:\/\/medizinonline.com\/es\/los-ninos-en-edad-escolar-primaria-tambien-se-benefician-de-los-efectos-calmantes\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/372530","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=372530"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/372530\/revisions"}],"predecessor-version":[{"id":372534,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/372530\/revisions\/372534"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/372533"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=372530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=372530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=372530"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=372530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}