{"id":384546,"date":"2024-09-05T00:01:00","date_gmt":"2024-09-04T22:01:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=384546"},"modified":"2024-09-27T11:04:50","modified_gmt":"2024-09-27T09:04:50","slug":"benefit-for-acute-bronchitis-and-colds","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/benefit-for-acute-bronchitis-and-colds\/","title":{"rendered":"Benefit for acute bronchitis and colds"},"content":{"rendered":"\n

A cold cough is rarely caused by bacteria; in the vast majority of cases, it is a symptom of a viral infection.\nSymptom-relieving preparations can alleviate the symptoms and shorten the duration of the illness.\nThe results of a meta-analysis by Kardos et al.\nshow that a standardized Pelargonium sidoides special extract alleviates cough symptoms, improves quality of life and reduces productivity losses. <\/strong><\/p>\n\n\n\n

In acute respiratory infections such as colds and bronchitis, cough is a leading symptom and a frequent reason for consultation in primary care [1].\nThe pathogen is often an influenza A or B virus with simultaneous or previous upper respiratory tract infection (rhinitis, sinusitis, pharyngitis, laryngitis).\nThe spontaneous course of uncomplicated acute bronchitis lasts on average around 2-3 weeks.\nAlthough viral cough symptoms are often self-limiting in otherwise healthy people, symptomatic treatment can be useful to reduce the level of suffering. <\/p>\n\n

Database with a total of over 2000 participants<\/h3>\n\n

The herbal medicine Kaloba\u00ae, which is based on the active ingredient EPs\u00ae 7630, is approved for the treatment of acute bronchitis in Switzerland and other countries [2].\nThe standardized Pelargonium sidoides extract EPs\u00ae 7630 is obtained from the roots of Cape geranium.\nIn numerous studies, EPs\u00ae 7630 showed a combination of antiviral, antibacterial and mucolytic effects.\nKardos et al.\nconducted a meta-analysis to find out more about the extent to which treatment with EPs\u00ae 7630 can reduce cough and improve disease-related quality of life [3].\nThey included 11 randomized, placebo-controlled trials investigating the efficacy of EPs\u00ae 7630 in acute bronchitis and the common cold.\nIn total, data from 2195 participants were included in the meta-analysis.\nIn three of the studies, the effects of the Pelargonium special extract were investigated in children\/adolescents and in adults with acute bronchitis respectively, and in five studies the focus was on the effects on the common cold.\nExplanations of the methodology used in the study are summarized in thebox<\/strong>.\nIt is important to note that in this context a ” risk ratio <\/em>” (R <\/em>R) >1.0 means that the probability of remission is higher with EPs\u00ae 7630 than with placebo. <\/p>\n\n

Methodology of the study: two-stage procedure<\/strong><\/td><\/tr>
Kardos et al.\nused a method in which the parameters of interest were first analyzed individually within each study and then combined in the sense of a classic meta-analysis.\nIn the first step, the cough scores were determined by calculating the intraindividual difference between the baseline value and day 5 or day 7.\nThese mean values and their estimated standard deviations were used as input for the meta-analyses performed in the second step.Response was defined as at least a 50% reduction in symptom severity or loss of quality of life compared to baseline.\nConsequently, higher rates indicate a more favorable outcome (e.g. a higher proportion of patients without any cough symptoms).\nThe resulting risk ratios >1.0 mean that the probability of remission is higher with EPs\u00ae 7630 than with placebo, i.e. the use of the phytotherapeutic agent has proven to be effective (RR=Risk Ratio). <\/td><\/tr>
to [3,4]<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n\n

Acute bronchitis: <\/strong>In children\/adolescents with acute bronchitis, 79.6% of participants treated with EPs\u00ae 7630 and 41% of the placebo group showed a reduction in cough intensity of at least 50% of baseline values on day 7 [3].\nThe risk ratio (RR) of EPs\u00ae 7630 to placebo was 1.86 (95% CI: 1.34-2.95).\nComplete cough remission occurred in 18.0% and 5.5% of study participants on EPs\u00ae 7630 and placebo respectively (RR: 2.91; 95% CI: 1.26-6.72). <\/p>\n\n

In adults with acute bronchitis, 88.7% of participants in the EPs\u00ae 7630 group and 47.6% in the placebo group showed a \u226550% response in terms of cough intensity (RR: 2.13; 95% CI: 1.37-3.31), while 26.0% and 6.3% no longer coughed on day 7 (RR: 5.00; 95% CI; 3.10-8.07).In addition, EPs\u00ae 7630 proved to be superior to placebo in terms of improvements in the performance of daily activities and in other quality of life measures.<\/p>\n\n

Common cold:<\/strong> With a normal cold, 56.8% of participants treated with EPs\u00ae 7630 and 38.8% of the placebo group showed a reduction in cough intensity of \u226550% on the fifth day (RR: 1.40; 95% CI: 1.19-1.65), while complete cough remission was seen in 26.1% and 18.4% with EPs\u00ae 7630 and placebo respectively (RR: 1.40; 95% CI: 1.06- 1.84) [3].\nIn addition, 48.8% and 41.5% of participants in the pelargonium arm were free of impairment in daily activities and pain\/discomfort, respectively, while the corresponding values for placebo were 38.2% and 38.6%. <\/p>\n\n

Conclusion<\/h3>\n\n

In summary, these results indicate that EPs\u00ae 7630 reduces the stress associated with acute bronchitis and colds and leads to an earlier remission of cough symptoms compared to the placebo [3].\nThe Pelargonium special extract also proved to be beneficial in terms of self-assessed quality of life.\nThe study authors emphasize that patients treated with the phytopharmacological preparation felt able to resume their usual daily activities earlier and thus had less loss of productivity [3]. <\/p>\n\n

Literature:<\/p>\n\n

    \n
  1. Kardos P: Akuter und chronischer Husten \u2013 gibt es etwas Neues? [Acute and chronic cough-What is new?]. Pneumologe (Berl) 2020;17(6): 433\u2013442.<\/li>\n\n\n\n
  2. Swissmedic: Medicinal product information, www.swissmedicinfo.ch,<\/a>(last accessed 24.07.2024)<\/li>\n\n\n\n
  3. Kardos P, et al.: Effects of Pelargonium sidoides extract EPs 7630 on acute cough and quality of life \u2013 a meta-analysis of randomized, placebo-controlled trials. Multidiscip Respir Med 2022 Aug 3; 17: 868.<\/li>\n\n\n\n
  4. Burke DL, Ensor J, Riley RD: Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ. Stat Med 2017; 36: 855\u2013875. <\/li>\n<\/ol>\n\n

    HAUSARZT PRAXIS 2024: 19(8): 26<\/em>PHYTOTHERAPIE PRAXIS 2024; 1(1): 15<\/em><\/p>\n\n

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