{"id":401314,"date":"2025-05-12T10:00:00","date_gmt":"2025-05-12T08:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/crohns-disease-step-up-or-top-down-therapy\/"},"modified":"2025-06-11T14:23:25","modified_gmt":"2025-06-11T12:23:25","slug":"crohns-disease-step-up-or-top-down-therapy","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/crohns-disease-step-up-or-top-down-therapy\/","title":{"rendered":"Crohn&#8217;s disease: step-up or top-down therapy?"},"content":{"rendered":"\n<p><strong>There are currently no clearly defined parameters available for therapy management, as the updated S3 guideline on the diagnosis and treatment of Crohn&#8217;s disease published last year states. This is a dilemma that raises the question of other indicators for evaluating the course of treatment. In the PROFILE study, a treatment strategy involving the early use of a biologic proved to be superior to the standard procedure in terms of steroid-free and surgery-free remission.  <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fcrohns-disease-step-up-or-top-down-therapy%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>There are currently no clearly defined parameters available for therapy management, as the updated S3 guideline on the diagnosis and treatment of Crohn&#8217;s disease published last year states. This is&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fcrohns-disease-step-up-or-top-down-therapy%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":401320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Chronic inflammatory bowel disease (IBD)  ","footnotes":""},"category":[11513,11391,11297,11548,11503],"tags":[11796,77397,11632,37019,83001,5878,83000],"powerkit_post_featured":[],"class_list":["post-401314","post","type-post","status-publish","format-standard","has-post-thumbnail","category-congress-reports","category-gastroenterology-and-hepatology","category-general-internal-medicine","category-rx-en","category-studies","tag-ced-en","tag-chronic-inflammatory-bowel-disease","tag-crohns-disease","tag-m-crohns","tag-step-up","tag-therapy","tag-top-down","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-19 03:08:54","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":401312,"slug":"maladie-de-crohn-traitement-step-up-ou-top-down","post_title":"Maladie de Crohn : traitement \"step-up\" ou \"top-down\" ?","href":"https:\/\/medizinonline.com\/fr\/maladie-de-crohn-traitement-step-up-ou-top-down\/"},"it_IT":{"locale":"it_IT","id":401327,"slug":"malattia-di-crohn-terapia-step-up-o-top-down","post_title":"Malattia di Crohn: terapia step-up o top-down?","href":"https:\/\/medizinonline.com\/it\/malattia-di-crohn-terapia-step-up-o-top-down\/"},"pt_PT":{"locale":"pt_PT","id":401322,"slug":"doenca-de-crohn-terapia-intensiva-ou-descendente","post_title":"Doen\u00e7a de Crohn: terapia intensiva ou descendente?","href":"https:\/\/medizinonline.com\/pt-pt\/doenca-de-crohn-terapia-intensiva-ou-descendente\/"},"es_ES":{"locale":"es_ES","id":401330,"slug":"enfermedad-de-crohn-terapia-ascendente-o-descendente","post_title":"Enfermedad de Crohn: \u00bfterapia ascendente o descendente?","href":"https:\/\/medizinonline.com\/es\/enfermedad-de-crohn-terapia-ascendente-o-descendente\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/401314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=401314"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/401314\/revisions"}],"predecessor-version":[{"id":401321,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/401314\/revisions\/401321"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/401320"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=401314"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=401314"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=401314"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=401314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}