{"id":404836,"date":"2025-07-23T14:05:00","date_gmt":"2025-07-23T12:05:00","guid":{"rendered":"https:\/\/medizinonline.com\/genotype-phenotype-correlations-in-pfic\/"},"modified":"2025-07-14T10:48:48","modified_gmt":"2025-07-14T08:48:48","slug":"genotype-phenotype-correlations-in-pfic","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/genotype-phenotype-correlations-in-pfic\/","title":{"rendered":"Genotype-phenotype correlations in PFIC"},"content":{"rendered":"\n<p><strong>The EASL guidelines on the clinical management of hereditary cholestatic liver disease, published in 2024, suggest that genetic testing should be performed as early as possible in the diagnostic process after ruling out common causes. Along with a better understanding of the genes and proteins involved in biliary homeostasis and the increasing availability of genetic testing, more and more patients with adult-onset cholestasis are being tested for cholestasis genes that play a role in progressive intrahepatic familial cholestasis (PFIC). <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fgenotype-phenotype-correlations-in-pfic%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The EASL guidelines on the clinical management of hereditary cholestatic liver disease, published in 2024, suggest that genetic testing should be performed as early as possible in the diagnostic process&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fgenotype-phenotype-correlations-in-pfic%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":404837,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Idiopathic cholestasis  ","footnotes":""},"category":[11513,11391,11297,11396,11548,11503],"tags":[84061,84062,24753,84063],"powerkit_post_featured":[],"class_list":["post-404836","post","type-post","status-publish","format-standard","has-post-thumbnail","category-congress-reports","category-gastroenterology-and-hepatology","category-general-internal-medicine","category-genetics","category-rx-en","category-studies","tag-easl-annual-meeting-en","tag-genotype-phenotype-correlations","tag-liver-disease","tag-pfic-en","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-14 23:25:15","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":404829,"slug":"correlations-genotype-phenotype-dans-la-pfic","post_title":"Corr\u00e9lations g\u00e9notype-ph\u00e9notype dans la PFIC","href":"https:\/\/medizinonline.com\/fr\/correlations-genotype-phenotype-dans-la-pfic\/"},"it_IT":{"locale":"it_IT","id":404806,"slug":"correlazioni-genotipo-fenotipo-nel-pfic","post_title":"Correlazioni genotipo-fenotipo nel PFIC","href":"https:\/\/medizinonline.com\/it\/correlazioni-genotipo-fenotipo-nel-pfic\/"},"pt_PT":{"locale":"pt_PT","id":404812,"slug":"correlacoes-genotipo-fenotipo-em-pfic","post_title":"Correla\u00e7\u00f5es gen\u00f3tipo-fen\u00f3tipo em PFIC","href":"https:\/\/medizinonline.com\/pt-pt\/correlacoes-genotipo-fenotipo-em-pfic\/"},"es_ES":{"locale":"es_ES","id":404809,"slug":"correlaciones-genotipo-fenotipo-en-la-pfic","post_title":"Correlaciones genotipo-fenotipo en la PFIC","href":"https:\/\/medizinonline.com\/es\/correlaciones-genotipo-fenotipo-en-la-pfic\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/404836","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=404836"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/404836\/revisions"}],"predecessor-version":[{"id":404839,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/404836\/revisions\/404839"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/404837"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=404836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=404836"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=404836"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=404836"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}