{"id":406526,"date":"2025-09-15T00:30:00","date_gmt":"2025-09-14T22:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/pathogenesis-based-and-nephroprotective-therapeutic-approaches\/"},"modified":"2025-09-15T14:08:16","modified_gmt":"2025-09-15T12:08:16","slug":"pathogenesis-based-and-nephroprotective-therapeutic-approaches","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/pathogenesis-based-and-nephroprotective-therapeutic-approaches\/","title":{"rendered":"Pathogenesis-based and nephroprotective therapeutic approaches"},"content":{"rendered":"\n<p><strong>Immunoglobulin (Ig) A nephropathy is considered an important cause of end-stage renal failure. Therefore, from today&#8217;s perspective, IgA nephropathy should not be classified as a benign disease. Fortunately, the treatment spectrum has expanded in recent years. In addition to oral TRF-budesonide and the DEARA drug sparsentan, which have now been approved in many countries, numerous pathogenesis-based therapies are currently in development. However, classic nephroprotective therapy options &#8211; RAAS-i, SGLT-2-i, MRA and GLP-1-RA &#8211; also continue to play an important role    <\/strong>.<\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fpathogenesis-based-and-nephroprotective-therapeutic-approaches%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Immunoglobulin (Ig) A nephropathy is considered an important cause of end-stage renal failure. Therefore, from today&#8217;s perspective, IgA nephropathy should not be classified as a benign disease. Fortunately, the treatment&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fpathogenesis-based-and-nephroprotective-therapeutic-approaches%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":126517,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Glomerulonephritis: IgA nephropathy  ","footnotes":""},"category":[11513,11391,11297,11413,11442,11548,11503],"tags":[84477,63911,65608,77612,68426,22755,18549,84478,84480,84479],"powerkit_post_featured":[],"class_list":["post-406526","post","type-post","status-publish","format-standard","has-post-thumbnail","category-congress-reports","category-gastroenterology-and-hepatology","category-general-internal-medicine","category-nephrology","category-pharmacology-and-toxicology","category-rx-en","category-studies","tag-deara-en","tag-glomerulonephritis-en-2","tag-glp-1-ra-en-2","tag-iga-nephropathy","tag-mra-en","tag-nephroprotection","tag-sglt-2-i-en","tag-sparsentan-en","tag-therapeutic-approaches-en","tag-trf-budesonide-en","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-15 12:55:13","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":406476,"slug":"approches-therapeutiques-basees-sur-la-pathogenese-et-la-nephroprotection","post_title":"Approches th\u00e9rapeutiques bas\u00e9es sur la pathogen\u00e8se et la n\u00e9phroprotection","href":"https:\/\/medizinonline.com\/fr\/approches-therapeutiques-basees-sur-la-pathogenese-et-la-nephroprotection\/"},"it_IT":{"locale":"it_IT","id":406490,"slug":"approcci-terapeutici-basati-sulla-patogenesi-e-sulla-nefroprotezione","post_title":"Approcci terapeutici basati sulla patogenesi e sulla nefroprotezione","href":"https:\/\/medizinonline.com\/it\/approcci-terapeutici-basati-sulla-patogenesi-e-sulla-nefroprotezione\/"},"pt_PT":{"locale":"pt_PT","id":406523,"slug":"abordagens-terapeuticas-baseadas-na-patogenese-e-na-nefroproteccao","post_title":"Abordagens terap\u00eauticas baseadas na patog\u00e9nese e na nefroprotec\u00e7\u00e3o","href":"https:\/\/medizinonline.com\/pt-pt\/abordagens-terapeuticas-baseadas-na-patogenese-e-na-nefroproteccao\/"},"es_ES":{"locale":"es_ES","id":406441,"slug":"enfoques-terapeuticos-basados-en-la-patogenesis-y-nefroprotectores","post_title":"Enfoques terap\u00e9uticos basados en la patog\u00e9nesis y nefroprotectores","href":"https:\/\/medizinonline.com\/es\/enfoques-terapeuticos-basados-en-la-patogenesis-y-nefroprotectores\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/406526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=406526"}],"version-history":[{"count":2,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/406526\/revisions"}],"predecessor-version":[{"id":408760,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/406526\/revisions\/408760"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/126517"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=406526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=406526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=406526"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=406526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}