{"id":408364,"date":"2025-09-30T13:30:00","date_gmt":"2025-09-30T11:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=408364"},"modified":"2025-09-11T10:23:36","modified_gmt":"2025-09-11T08:23:36","slug":"nanoparticle-mediated-intratumoral-gene-editing-of-pd-l1-and-galectin-9","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/nanoparticle-mediated-intratumoral-gene-editing-of-pd-l1-and-galectin-9\/","title":{"rendered":"Nanoparticle-mediated intratumoral gene editing of PD-L1 and galectin-9"},"content":{"rendered":"\n

Immune checkpoint inhibitors (ICI) have revolutionized oncological therapy, but many patients do not respond or only respond inadequately to this form of treatment. Resistance mechanisms such as the overexpression of PD-L1 or immunosuppressive molecules such as galectin-9 limit their effectiveness. A novel approach aims at targeted intratumoral gene editing using nanoparticles that introduce CRISPR-Cas components directly into tumor cells and switch off regulatory genes there. A recent study provides preclinical evidence that the combined silencing of PD-L1 and galectin-9 significantly inhibits tumor growth and improves the efficacy of ICI therapies. <\/strong><\/p>\n\n

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Immune checkpoint inhibitors (ICI) have revolutionized oncological therapy, but many patients do not respond or only respond inadequately to this form of treatment. Resistance mechanisms such as the overexpression of……... <\/p>\n

Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich
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Already a member? Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":408365,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"New perspectives for the optimization of cancer immunotherapy","footnotes":""},"category":[11508,11370,11548,11503],"tags":[85220,13546,42007],"powerkit_post_featured":[],"class_list":["post-408364","post","type-post","status-publish","format-standard","has-post-thumbnail","category-education","category-oncology","category-rx-en","category-studies","tag-galectin-9-en","tag-immunotherapy","tag-pd-l1-en","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-14 14:31:35","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":408373,"slug":"edition-de-genes-intratumoraux-de-pd-l1-et-de-galectine-9-mediee-par-des-nanoparticules","post_title":"\u00c9dition de g\u00e8nes intratumoraux de PD-L1 et de galectine-9 m\u00e9di\u00e9e par des nanoparticules","href":"https:\/\/medizinonline.com\/fr\/edition-de-genes-intratumoraux-de-pd-l1-et-de-galectine-9-mediee-par-des-nanoparticules\/"},"it_IT":{"locale":"it_IT","id":408352,"slug":"editing-genico-intratumorale-mediato-da-nanoparticelle-di-pd-l1-e-galectina-9","post_title":"Editing genico intratumorale mediato da nanoparticelle di PD-L1 e galectina-9","href":"https:\/\/medizinonline.com\/it\/editing-genico-intratumorale-mediato-da-nanoparticelle-di-pd-l1-e-galectina-9\/"},"pt_PT":{"locale":"pt_PT","id":408398,"slug":"edicao-genetica-intratumoral-de-pd-l1-e-galectina-9-mediada-por-nanoparticulas","post_title":"Edi\u00e7\u00e3o gen\u00e9tica intratumoral de PD-L1 e galectina-9 mediada por nanopart\u00edculas","href":"https:\/\/medizinonline.com\/pt-pt\/edicao-genetica-intratumoral-de-pd-l1-e-galectina-9-mediada-por-nanoparticulas\/"},"es_ES":{"locale":"es_ES","id":408392,"slug":"edicion-genica-intratumoral-mediada-por-nanoparticulas-de-pd-l1-y-galectina-9","post_title":"Edici\u00f3n g\u00e9nica intratumoral mediada por nanopart\u00edculas de PD-L1 y galectina-9","href":"https:\/\/medizinonline.com\/es\/edicion-genica-intratumoral-mediada-por-nanoparticulas-de-pd-l1-y-galectina-9\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/408364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=408364"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/408364\/revisions"}],"predecessor-version":[{"id":408366,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/408364\/revisions\/408366"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/408365"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=408364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=408364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=408364"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=408364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}