{"id":408730,"date":"2025-08-24T10:25:00","date_gmt":"2025-08-24T08:25:00","guid":{"rendered":"https:\/\/medizinonline.com\/anti-nephrin-autoantibodies-in-steroid-resistant-nephrotic-syndrome\/"},"modified":"2025-09-12T11:18:56","modified_gmt":"2025-09-12T09:18:56","slug":"anti-nephrin-autoantibodies-in-steroid-resistant-nephrotic-syndrome","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/anti-nephrin-autoantibodies-in-steroid-resistant-nephrotic-syndrome\/","title":{"rendered":"Anti-nephrin autoantibodies in steroid-resistant nephrotic syndrome"},"content":{"rendered":"\n

The understanding of idiopathic nephrotic syndrome (INS) is changing. While the majority of children with a steroid-sensitive or steroid-dependent course can be brought into remission with glucocorticoids and further immunosuppression, the steroid-resistant form remains a clinical challenge. The discovery of autoantibodies against the podocytic slit diaphragm protein nephrin opens up a new pathogenetic paradigm. A large multicenter study now shows that anti-nephrin autoantibodies are mainly found in steroid-sensitive and steroid-dependent courses, while they are largely absent in genetically determined or multidrug-resistant forms. This suggests that anti-nephrin antibodies not only reflect pathogenesis and prognosis, but could also guide therapeutic decisions. <\/strong><\/p>\n\n

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The understanding of idiopathic nephrotic syndrome (INS) is changing. While the majority of children with a steroid-sensitive or steroid-dependent course can be brought into remission with glucocorticoids and further immunosuppression,……... <\/p>\n

Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich
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