{"id":408731,"date":"2025-08-25T12:00:00","date_gmt":"2025-08-25T10:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/from-podocyte-pathophysiology-to-personalized-therapy\/"},"modified":"2025-09-12T11:18:57","modified_gmt":"2025-09-12T09:18:57","slug":"from-podocyte-pathophysiology-to-personalized-therapy","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/from-podocyte-pathophysiology-to-personalized-therapy\/","title":{"rendered":"From podocyte pathophysiology to personalized therapy"},"content":{"rendered":"\n<p><strong>Idiopathic nephrotic syndrome (INS) is the most common glomerular disease in childhood. For a long time, it was considered a clinically defined, non-specific entity whose treatment was primarily based on glucocorticoid sensitivity. However, new findings paint a more precise picture: Idiopathic nephrotic syndrome &#8211; especially the steroid-sensitive form &#8211; is to be understood in essential parts as an autoimmune-driven disease in which B-cell dysregulation, autoantibodies against podocytic antigens and genetic predispositions interact. This opens up a new paradigm in pathogenesis, diagnostics and therapy, paving the way for individualized approaches.   <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Ffrom-podocyte-pathophysiology-to-personalized-therapy%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Idiopathic nephrotic syndrome (INS) is the most common glomerular disease in childhood. For a long time, it was considered a clinically defined, non-specific entity whose treatment was primarily based on&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Ffrom-podocyte-pathophysiology-to-personalized-therapy%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":408734,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"The autoimmune architecture of the child's INS","footnotes":""},"category":[11508,11396,11413,11437,11548,11503,11490],"tags":[85302,85303,39865],"powerkit_post_featured":[],"class_list":["post-408731","post","type-post","status-publish","format-standard","has-post-thumbnail","category-education","category-genetics","category-nephrology","category-pediatrics","category-rx-en","category-studies","category-urology","tag-idiopathic-nephrotic-syndrome","tag-ins-en","tag-proteinuria","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-27 11:14:07","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":408725,"slug":"de-la-physiopathologie-des-podocytes-a-la-therapie-personnalisee","post_title":"De la physiopathologie des podocytes \u00e0 la th\u00e9rapie personnalis\u00e9e","href":"https:\/\/medizinonline.com\/fr\/de-la-physiopathologie-des-podocytes-a-la-therapie-personnalisee\/"},"it_IT":{"locale":"it_IT","id":408719,"slug":"dalla-fisiopatologia-dei-podociti-alla-terapia-personalizzata","post_title":"Dalla fisiopatologia dei podociti alla terapia personalizzata","href":"https:\/\/medizinonline.com\/it\/dalla-fisiopatologia-dei-podociti-alla-terapia-personalizzata\/"},"pt_PT":{"locale":"pt_PT","id":408713,"slug":"da-fisiopatologia-dos-podocitos-a-terapia-personalizada","post_title":"Da fisiopatologia dos pod\u00f3citos \u00e0 terapia personalizada","href":"https:\/\/medizinonline.com\/pt-pt\/da-fisiopatologia-dos-podocitos-a-terapia-personalizada\/"},"es_ES":{"locale":"es_ES","id":408707,"slug":"de-la-fisiopatologia-podocitaria-a-la-terapia-personalizada","post_title":"De la fisiopatolog\u00eda podocitaria a la terapia personalizada","href":"https:\/\/medizinonline.com\/es\/de-la-fisiopatologia-podocitaria-a-la-terapia-personalizada\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/408731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=408731"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/408731\/revisions"}],"predecessor-version":[{"id":408735,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/408731\/revisions\/408735"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/408734"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=408731"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=408731"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=408731"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=408731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}