{"id":409087,"date":"2025-09-15T05:00:00","date_gmt":"2025-09-15T03:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/real-world-data-on-thrombosis-predictors-and-c5-complement-inhibitors\/"},"modified":"2025-09-27T09:08:57","modified_gmt":"2025-09-27T07:08:57","slug":"real-world-data-on-thrombosis-predictors-and-c5-complement-inhibitors","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/real-world-data-on-thrombosis-predictors-and-c5-complement-inhibitors\/","title":{"rendered":"Real-world data on thrombosis predictors and C5 complement inhibitors"},"content":{"rendered":"\n<p><strong>Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired disease of haematopoietic stem cells of the bone marrow. GPI deficiency results in the absence of complement-regulating proteins. Thromboembolic complications are the most clinically relevant complication and are the main cause of increased morbidity and mortality. Inhibition of the terminal complement system is a targeted therapeutic strategy. Eculizumab and crovalimab bind the complement factor C5 and have proven to be effective and safe treatment options.      <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Freal-world-data-on-thrombosis-predictors-and-c5-complement-inhibitors%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired disease of haematopoietic stem cells of the bone marrow. GPI deficiency results in the absence of complement-regulating proteins. Thromboembolic complications are the&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Freal-world-data-on-thrombosis-predictors-and-c5-complement-inhibitors%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":409089,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Paroxysmal nocturnal hemoglobinuria","footnotes":""},"category":[11513,11353,11370,11548,11503],"tags":[12958,85381,85383,85384,46755,18935,46761,21103],"powerkit_post_featured":[],"class_list":["post-409087","post","type-post","status-publish","format-standard","has-post-thumbnail","category-congress-reports","category-hematology","category-oncology","category-rx-en","category-studies","tag-bone-marrow","tag-complement-factor-c5","tag-complement-system","tag-crovalimab-en","tag-eculizumab-en","tag-paroxysmal-nocturnal-hemoglobinuria","tag-pnh-en","tag-stem-cells","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-08 06:41:13","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":409081,"slug":"donnees-du-monde-reel-sur-les-predicteurs-de-thrombose-et-les-inhibiteurs-du-complement-c5","post_title":"Donn\u00e9es du monde r\u00e9el sur les pr\u00e9dicteurs de thrombose et les inhibiteurs du compl\u00e9ment C5","href":"https:\/\/medizinonline.com\/fr\/donnees-du-monde-reel-sur-les-predicteurs-de-thrombose-et-les-inhibiteurs-du-complement-c5\/"},"it_IT":{"locale":"it_IT","id":409074,"slug":"dati-del-mondo-reale-sui-predittori-di-trombosi-e-sugli-inibitori-del-complemento-c5","post_title":"Dati del mondo reale sui predittori di trombosi e sugli inibitori del complemento C5","href":"https:\/\/medizinonline.com\/it\/dati-del-mondo-reale-sui-predittori-di-trombosi-e-sugli-inibitori-del-complemento-c5\/"},"pt_PT":{"locale":"pt_PT","id":409098,"slug":"dados-do-mundo-real-sobre-preditores-de-trombose-e-inibidores-do-complemento-c5","post_title":"Dados do mundo real sobre preditores de trombose e inibidores do complemento C5","href":"https:\/\/medizinonline.com\/pt-pt\/dados-do-mundo-real-sobre-preditores-de-trombose-e-inibidores-do-complemento-c5\/"},"es_ES":{"locale":"es_ES","id":409101,"slug":"datos-reales-sobre-predictores-de-trombosis-e-inhibidores-del-complemento-c5","post_title":"Datos reales sobre predictores de trombosis e inhibidores del complemento C5","href":"https:\/\/medizinonline.com\/es\/datos-reales-sobre-predictores-de-trombosis-e-inhibidores-del-complemento-c5\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/409087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=409087"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/409087\/revisions"}],"predecessor-version":[{"id":409091,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/409087\/revisions\/409091"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/409089"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=409087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=409087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=409087"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=409087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}