{"id":409789,"date":"2025-11-25T00:30:00","date_gmt":"2025-11-24T23:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=409789"},"modified":"2025-10-16T18:28:52","modified_gmt":"2025-10-16T16:28:52","slug":"hypercholesterolemia","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/hypercholesterolemia\/","title":{"rendered":"Hypercholesterolemia"},"content":{"rendered":"\n<p><strong>The past 18 months have noticeably shifted the LDL-lowering landscape: An ESC\/EAS-Focused Update 2025 sharpens the indication thresholds, real-world data confirm the benefit of early combinations after myocardial infarction, bempedoic acid confirms robust outcome effects in statin intolerance, siRNA therapy gains reach &#8211; and positive phase 3 topline results on an oral PCSK9 inhibitor are available for the first time. This review distills the latest evidence and translates it into consistent strategies for cardiac care &#8211; focusing on secondary prevention, statin intolerance, FH subgroups and the safety of very low LDL-C levels. <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fhypercholesterolemia%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The past 18 months have noticeably shifted the LDL-lowering landscape: An ESC\/EAS-Focused Update 2025 sharpens the indication thresholds, real-world data confirm the benefit of early combinations after myocardial infarction, bempedoic&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fhypercholesterolemia%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":409790,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Update 2025","footnotes":""},"category":[11359,11508,11384,11548,11503],"tags":[85496,18144,20827,20539,69342],"powerkit_post_featured":[],"class_list":["post-409789","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cardiology","category-education","category-endocrinology-and-diabetology","category-rx-en","category-studies","tag-bempedoic-acid-2","tag-cholesterol","tag-myocardial-infarction","tag-pcsk9-en","tag-statin-intolerance-en","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-05 05:15:41","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":409766,"slug":"hypercholesterolemie","post_title":"Hypercholest\u00e9rol\u00e9mie","href":"https:\/\/medizinonline.com\/fr\/hypercholesterolemie\/"},"it_IT":{"locale":"it_IT","id":409772,"slug":"ipercolesterolemia","post_title":"Ipercolesterolemia","href":"https:\/\/medizinonline.com\/it\/ipercolesterolemia\/"},"pt_PT":{"locale":"pt_PT","id":409786,"slug":"hipercolesterolemia","post_title":"Hipercolesterolemia","href":"https:\/\/medizinonline.com\/pt-pt\/hipercolesterolemia\/"},"es_ES":{"locale":"es_ES","id":409781,"slug":"hipercolesterolemia","post_title":"Hipercolesterolemia","href":"https:\/\/medizinonline.com\/es\/hipercolesterolemia\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/409789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=409789"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/409789\/revisions"}],"predecessor-version":[{"id":409791,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/409789\/revisions\/409791"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/409790"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=409789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=409789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=409789"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=409789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}