{"id":410358,"date":"2025-11-17T00:30:00","date_gmt":"2025-11-16T23:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=410358"},"modified":"2025-10-23T14:41:53","modified_gmt":"2025-10-23T12:41:53","slug":"when-the-skin-becomes-agony","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/when-the-skin-becomes-agony\/","title":{"rendered":"When the skin becomes agony"},"content":{"rendered":"\n<p><strong>The agonizing itching is one of the most difficult symptoms to bear in patients with primary biliary cholangitis (PBC). It can have a far greater impact on everyday life, sleep and mental stability than the laboratory values of the underlying disease. New studies and congress papers from 2025 show that the therapeutic spectrum has expanded significantly in recent years. The focus today is on the targeted modulation of cholestatic mechanisms, in particular through inhibitors of bile acid transport and PPAR agonists, which not only have a favorable effect on the course of the disease but also on the symptom burden.   <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fwhen-the-skin-becomes-agony%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The agonizing itching is one of the most difficult symptoms to bear in patients with primary biliary cholangitis (PBC). It can have a far greater impact on everyday life, sleep&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fwhen-the-skin-becomes-agony%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":410361,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Itching in primary biliary cholangitis","footnotes":""},"category":[11331,11340,11508,11391,11297,11548,11503],"tags":[32456,85597,18526],"powerkit_post_featured":[],"class_list":["post-410358","post","type-post","status-publish","format-standard","has-post-thumbnail","category-allergology-and-clinical-immunology","category-dermatology-and-venereology","category-education","category-gastroenterology-and-hepatology","category-general-internal-medicine","category-rx-en","category-studies","tag-pbc-en","tag-primary-biliary-cholangitis-2","tag-pruritus-en","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-17 12:59:29","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":410460,"slug":"quand-la-peau-devient-une-souffrance","post_title":"Quand la peau devient une souffrance","href":"https:\/\/medizinonline.com\/fr\/quand-la-peau-devient-une-souffrance\/"},"it_IT":{"locale":"it_IT","id":410475,"slug":"quando-la-pelle-diventa-un-dolore","post_title":"Quando la pelle diventa un dolore","href":"https:\/\/medizinonline.com\/it\/quando-la-pelle-diventa-un-dolore\/"},"pt_PT":{"locale":"pt_PT","id":410349,"slug":"quando-a-pele-se-torna-uma-dor","post_title":"Quando a pele se torna uma dor","href":"https:\/\/medizinonline.com\/pt-pt\/quando-a-pele-se-torna-uma-dor\/"},"es_ES":{"locale":"es_ES","id":410468,"slug":"cuando-la-piel-se-vuelve-un-dolor","post_title":"Cuando la piel se vuelve un dolor","href":"https:\/\/medizinonline.com\/es\/cuando-la-piel-se-vuelve-un-dolor\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/410358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=410358"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/410358\/revisions"}],"predecessor-version":[{"id":410362,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/410358\/revisions\/410362"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/410361"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=410358"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=410358"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=410358"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=410358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}