{"id":411327,"date":"2025-11-24T13:30:00","date_gmt":"2025-11-24T12:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/therapeutic-rationale-for-targeted-il-36-receptor-inhibition\/"},"modified":"2025-10-30T17:02:21","modified_gmt":"2025-10-30T16:02:21","slug":"therapeutic-rationale-for-targeted-il-36-receptor-inhibition","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/therapeutic-rationale-for-targeted-il-36-receptor-inhibition\/","title":{"rendered":"Therapeutic rationale for targeted IL-36 receptor inhibition"},"content":{"rendered":"\n

The progress in the diagnosis and treatment of generalized pustular psoriasis (GPP) is remarkable. GPP has developed into a clearly defined, independent, IL-36-mediated autoinflammatory disease. Today, the high chronic disease burden far beyond the acute flare-ups is recognized. With the introduction of IL-36 receptor inhibitors, a highly effective, rapid onset, pathophysiology-based therapy is available for the first time. <\/strong><\/p>\n\n

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The progress in the diagnosis and treatment of generalized pustular psoriasis (GPP) is remarkable. GPP has developed into a clearly defined, independent, IL-36-mediated autoinflammatory disease. Today, the high chronic disease……... <\/p>\n

Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich
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Already a member? Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":411328,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"GPP: from molecular principles to targeted therapy ","footnotes":""},"category":[11331,11513,11340,11406,11548,11503],"tags":[65706,70962,85902,85903,85901,83516,36635,75847,85904,85900],"powerkit_post_featured":[],"class_list":["post-411327","post","type-post","status-publish","format-standard","has-post-thumbnail","category-allergology-and-clinical-immunology","category-congress-reports","category-dermatology-and-venereology","category-infectiology","category-rx-en","category-studies","tag-annual-congress","tag-gpp-en","tag-il-36-receptor-inhibition","tag-interleukin-36","tag-molecular-basics","tag-pustular-psoriasis","tag-sgdv-en","tag-spesolimab-en","tag-targeted-therapy-2","tag-therapeutic-rationale","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-18 11:38:39","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":411322,"slug":"role-therapeutique-de-linhibition-ciblee-du-recepteur-de-lil-36","post_title":"R\u00f4le th\u00e9rapeutique de l'inhibition cibl\u00e9e du r\u00e9cepteur de l'IL-36","href":"https:\/\/medizinonline.com\/fr\/role-therapeutique-de-linhibition-ciblee-du-recepteur-de-lil-36\/"},"it_IT":{"locale":"it_IT","id":411313,"slug":"razionale-terapeutico-per-linibizione-mirata-del-recettore-il-36","post_title":"Razionale terapeutico per l'inibizione mirata del recettore IL-36","href":"https:\/\/medizinonline.com\/it\/razionale-terapeutico-per-linibizione-mirata-del-recettore-il-36\/"},"pt_PT":{"locale":"pt_PT","id":411304,"slug":"justificacao-terapeutica-para-a-inibicao-especifica-do-recetor-il-36","post_title":"Justifica\u00e7\u00e3o terap\u00eautica para a inibi\u00e7\u00e3o espec\u00edfica do recetor IL-36","href":"https:\/\/medizinonline.com\/pt-pt\/justificacao-terapeutica-para-a-inibicao-especifica-do-recetor-il-36\/"},"es_ES":{"locale":"es_ES","id":411451,"slug":"justificacion-terapeutica-de-la-inhibicion-dirigida-del-receptor-de-la-il-36","post_title":"Justificaci\u00f3n terap\u00e9utica de la inhibici\u00f3n dirigida del receptor de la IL-36","href":"https:\/\/medizinonline.com\/es\/justificacion-terapeutica-de-la-inhibicion-dirigida-del-receptor-de-la-il-36\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/411327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=411327"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/411327\/revisions"}],"predecessor-version":[{"id":411329,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/411327\/revisions\/411329"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/411328"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=411327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=411327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=411327"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=411327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}