{"id":411497,"date":"2025-11-20T13:30:00","date_gmt":"2025-11-20T12:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=411497"},"modified":"2025-11-20T14:29:43","modified_gmt":"2025-11-20T13:29:43","slug":"topical-pan-jak-i-vs-systemic-retinoid-head-to-head-study","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/topical-pan-jak-i-vs-systemic-retinoid-head-to-head-study\/","title":{"rendered":"Topical pan-JAK-i vs. systemic retinoid: head-to-head study"},"content":{"rendered":"\n<p><strong>Alitretinoin is currently the only systemic treatment approved for severe chronic hand eczema when patients do not respond adequately to topical corticosteroids. The topical pan-Janus kinase (JAK) inhibitor delgocitinib is now also available as a further escalation option for these cases. In the DELTA-FORCE study, the two treatment options were directly compared, with delgocitinib proving to be superior.  <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Ftopical-pan-jak-i-vs-systemic-retinoid-head-to-head-study%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Alitretinoin is currently the only systemic treatment approved for severe chronic hand eczema when patients do not respond adequately to topical corticosteroids. The topical pan-Janus kinase (JAK) inhibitor delgocitinib is&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Ftopical-pan-jak-i-vs-systemic-retinoid-head-to-head-study%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":411498,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Chronic hand eczema  ","footnotes":""},"category":[11331,11340,11508,11406,11548,11503],"tags":[82466,33066,80615,86011,86009,86010,14239],"powerkit_post_featured":[],"class_list":["post-411497","post","type-post","status-publish","format-standard","has-post-thumbnail","category-allergology-and-clinical-immunology","category-dermatology-and-venereology","category-education","category-infectiology","category-rx-en","category-studies","tag-anzupgo-en","tag-chronic-hand-eczema","tag-delgocitinib-en","tag-delta-force","tag-head-to-head-study","tag-systemic-retinoid","tag-topical","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-22 07:59:08","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":411494,"slug":"pan-jak-i-topique-vs-retinoide-systemique-etude-en-tete-a-tete","post_title":"pan-JAK-i topique vs. r\u00e9tino\u00efde syst\u00e9mique : \u00e9tude en t\u00eate-\u00e0-t\u00eate","href":"https:\/\/medizinonline.com\/fr\/pan-jak-i-topique-vs-retinoide-systemique-etude-en-tete-a-tete\/"},"it_IT":{"locale":"it_IT","id":411491,"slug":"pan-jak-i-topico-vs-retinoide-sistemico-studio-testa-a-testa","post_title":"Pan-JAK-i topico vs. retinoide sistemico: studio testa a testa","href":"https:\/\/medizinonline.com\/it\/pan-jak-i-topico-vs-retinoide-sistemico-studio-testa-a-testa\/"},"pt_PT":{"locale":"pt_PT","id":411488,"slug":"pan-jak-i-topico-vs-retinoide-sistemico-estudo-comparativo","post_title":"Pan-JAK-i t\u00f3pico vs. retinoide sist\u00e9mico: estudo comparativo","href":"https:\/\/medizinonline.com\/pt-pt\/pan-jak-i-topico-vs-retinoide-sistemico-estudo-comparativo\/"},"es_ES":{"locale":"es_ES","id":411485,"slug":"pan-jak-i-topico-frente-a-retinoide-sistemico-estudio-comparativo","post_title":"Pan-JAK-i t\u00f3pico frente a retinoide sist\u00e9mico: estudio comparativo","href":"https:\/\/medizinonline.com\/es\/pan-jak-i-topico-frente-a-retinoide-sistemico-estudio-comparativo\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/411497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=411497"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/411497\/revisions"}],"predecessor-version":[{"id":411499,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/411497\/revisions\/411499"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/411498"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=411497"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=411497"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=411497"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=411497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}