{"id":411795,"date":"2025-11-25T13:30:00","date_gmt":"2025-11-25T12:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=411795"},"modified":"2025-11-03T12:02:53","modified_gmt":"2025-11-03T11:02:53","slug":"enpp1-as-a-biomarker-for-poor-prognosis-and-early-detection-of-brain-metastases","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/enpp1-as-a-biomarker-for-poor-prognosis-and-early-detection-of-brain-metastases\/","title":{"rendered":"ENPP1 as a biomarker for poor prognosis and early detection of brain metastases"},"content":{"rendered":"\n

Around 15-20% of all breast cancer cases are HER2-positive, which is a subtype with an aggressive course and an increased tendency to metastasize to the brain. A new study now shows that the enzyme ENPP1 undermines the barrier function of the blood-brain barrier (BBB) and can serve as a potential biomarker for the early phase of the development of brain metastases in HER2-positive breast cancer, meaning that ENPP1 inhibitors<\/em>can be used in future as a complementary strategy to prevent metastasis, especially in patients with high ENPP1 expression and proven BBB dysfunction. <\/strong><\/p>\n\n

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Around 15-20% of all breast cancer cases are HER2-positive, which is a subtype with an aggressive course and an increased tendency to metastasize to the brain. A new study now……... <\/p>\n

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