{"id":411825,"date":"2025-11-05T00:30:00","date_gmt":"2025-11-04T23:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=411825"},"modified":"2025-11-03T12:03:50","modified_gmt":"2025-11-03T11:03:50","slug":"consideration-of-the-tumor-microenvironment-opens-up-new-treatment-options","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/consideration-of-the-tumor-microenvironment-opens-up-new-treatment-options\/","title":{"rendered":"Consideration of the tumor microenvironment opens up new treatment options"},"content":{"rendered":"\n<p><strong>Low-grade gliomas are among the most common primary brain tumors in childhood and can affect patients for life, which is why early diagnosis involving the tumor microenvironment is of significant importance. An international study published in 2025, in which the researchers used imaging mass cytometry to examine over 100 tumor samples at the single-cell level, revealed new therapeutic approaches with the potential combination of blocking the immune checkpoint receptor TIM-3 expressed on myeloid cells with inhibition of the MAPK signaling pathway. <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fconsideration-of-the-tumor-microenvironment-opens-up-new-treatment-options%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Low-grade gliomas are among the most common primary brain tumors in childhood and can affect patients for life, which is why early diagnosis involving the tumor microenvironment is of significant&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fconsideration-of-the-tumor-microenvironment-opens-up-new-treatment-options%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":411828,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Low-grade pediatric gliomas","footnotes":""},"category":[22615,11363,11370,11437,11548,11380],"tags":[86115,86117,75859,86118,86116],"powerkit_post_featured":[],"class_list":["post-411825","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cme-continuing-education","category-neurology","category-oncology","category-pediatrics","category-rx-en","category-surgery","tag-low-grade-pediatric-gliomas","tag-makp-signaling-pathway-inhibition","tag-mass-cytometry","tag-tim-3-blockade","tag-tumor-microenvironment","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-06 09:19:13","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":411826,"slug":"la-prise-en-compte-du-microenvironnement-tumoral-ouvre-de-nouvelles-options-therapeutiques","post_title":"La prise en compte du microenvironnement tumoral ouvre de nouvelles options th\u00e9rapeutiques","href":"https:\/\/medizinonline.com\/fr\/la-prise-en-compte-du-microenvironnement-tumoral-ouvre-de-nouvelles-options-therapeutiques\/"},"it_IT":{"locale":"it_IT","id":411827,"slug":"la-considerazione-del-microambiente-tumorale-apre-nuove-opzioni-di-trattamento","post_title":"La considerazione del microambiente tumorale apre nuove opzioni di trattamento.","href":"https:\/\/medizinonline.com\/it\/la-considerazione-del-microambiente-tumorale-apre-nuove-opzioni-di-trattamento\/"},"pt_PT":{"locale":"pt_PT","id":411840,"slug":"a-consideracao-do-microambiente-tumoral-abre-novas-opcoes-de-tratamento","post_title":"A considera\u00e7\u00e3o do microambiente tumoral abre novas op\u00e7\u00f5es de tratamento","href":"https:\/\/medizinonline.com\/pt-pt\/a-consideracao-do-microambiente-tumoral-abre-novas-opcoes-de-tratamento\/"},"es_ES":{"locale":"es_ES","id":411829,"slug":"la-consideracion-del-microentorno-tumoral-abre-nuevas-opciones-de-tratamiento","post_title":"La consideraci\u00f3n del microentorno tumoral abre nuevas opciones de tratamiento","href":"https:\/\/medizinonline.com\/es\/la-consideracion-del-microentorno-tumoral-abre-nuevas-opciones-de-tratamiento\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/411825","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=411825"}],"version-history":[{"count":3,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/411825\/revisions"}],"predecessor-version":[{"id":411838,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/411825\/revisions\/411838"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/411828"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=411825"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=411825"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=411825"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=411825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}