{"id":449795,"date":"2026-01-05T00:03:00","date_gmt":"2026-01-04T23:03:00","guid":{"rendered":"https:\/\/medizinonline.com\/how-can-the-risk-benefit-profile-be-improved\/"},"modified":"2026-01-04T22:44:28","modified_gmt":"2026-01-04T21:44:28","slug":"how-can-the-risk-benefit-profile-be-improved","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/how-can-the-risk-benefit-profile-be-improved\/","title":{"rendered":"How can the risk-benefit profile be improved?"},"content":{"rendered":"\n<p><strong>Acute pancreatitis is a life-threatening complication in patients with familial chylomicronemia syndrome. With olezarsen and plozasiran, two innovative drug candidates have been developed for which promising Phase III data are now available. With regard to patients with chronic pancreatitis and abdominal pain, interesting long-term data are available from a cohort study in which prompt surgery was compared with endoscopy as first-line therapy.  <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fhow-can-the-risk-benefit-profile-be-improved%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Acute pancreatitis is a life-threatening complication in patients with familial chylomicronemia syndrome. With olezarsen and plozasiran, two innovative drug candidates have been developed for which promising Phase III data are&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fhow-can-the-risk-benefit-profile-be-improved%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":449796,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Treatment of pancreatitis: current study data","footnotes":""},"category":[11513,11391,11297,11548,11503],"tags":[86944,29838,68004,86942,86945,86946,86943,14523,86947],"powerkit_post_featured":[],"class_list":["post-449795","post","type-post","status-publish","format-standard","has-post-thumbnail","category-congress-reports","category-gastroenterology-and-hepatology","category-general-internal-medicine","category-rx-en","category-studies","tag-acute-pancreatitis","tag-benefit-risk-profile","tag-chronic-pancreatitis","tag-chylomicronemia","tag-chylomicronemia-syndrome","tag-current-study-data","tag-olezarsen","tag-pancreatitis-en","tag-plozasiran","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-17 12:03:59","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":449791,"slug":"comment-ameliorer-le-profil-benefice-risque","post_title":"Comment am\u00e9liorer le profil b\u00e9n\u00e9fice\/risque ?","href":"https:\/\/medizinonline.com\/fr\/comment-ameliorer-le-profil-benefice-risque\/"},"it_IT":{"locale":"it_IT","id":449784,"slug":"come-si-puo-migliorare-il-profilo-rischio-beneficio","post_title":"Come si pu\u00f2 migliorare il profilo rischio-beneficio?","href":"https:\/\/medizinonline.com\/it\/come-si-puo-migliorare-il-profilo-rischio-beneficio\/"},"pt_PT":{"locale":"pt_PT","id":449775,"slug":"como-pode-melhorar-o-perfil-de-risco-beneficio","post_title":"Como pode melhorar o perfil de risco-benef\u00edcio?","href":"https:\/\/medizinonline.com\/pt-pt\/como-pode-melhorar-o-perfil-de-risco-beneficio\/"},"es_ES":{"locale":"es_ES","id":449769,"slug":"como-puede-mejorarse-el-perfil-riesgo-beneficio","post_title":"\u00bfC\u00f3mo puede mejorarse el perfil riesgo-beneficio?","href":"https:\/\/medizinonline.com\/es\/como-puede-mejorarse-el-perfil-riesgo-beneficio\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/449795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=449795"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/449795\/revisions"}],"predecessor-version":[{"id":449797,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/449795\/revisions\/449797"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/449796"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=449795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=449795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=449795"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=449795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}