{"id":459426,"date":"2026-01-25T00:30:00","date_gmt":"2026-01-24T23:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=459426"},"modified":"2026-01-25T09:27:33","modified_gmt":"2026-01-25T08:27:33","slug":"symptomatic-obstructive-hypertrophic-cardiomyopathy","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/symptomatic-obstructive-hypertrophic-cardiomyopathy\/","title":{"rendered":"Symptomatic obstructive hypertrophic cardiomyopathy"},"content":{"rendered":"\n<p><strong>Myosin inhibition is considered a key therapeutic approach in the treatment of obstructive hypertrophic cardiomyopathy (oHCM). In addition to mavacamten, aficamten is now being clinically investigated as a potentially short-acting, specific myosin inhibitor. The FOREST-HCM study provides the first systematically collected 48-week data on efficacy, safety and functional changes under long-term treatment. The results provide relevant insights into the stability of gradient reduction, symptom control and tolerability of the drug in continuous use.   <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fsymptomatic-obstructive-hypertrophic-cardiomyopathy%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Myosin inhibition is considered a key therapeutic approach in the treatment of obstructive hypertrophic cardiomyopathy (oHCM). In addition to mavacamten, aficamten is now being clinically investigated as a potentially short-acting,&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fsymptomatic-obstructive-hypertrophic-cardiomyopathy%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":459427,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Results of the FOREST HCM study  ","footnotes":""},"category":[11359,11508,11548,11503],"tags":[87434,14711,87435,87436,34823,87433,87437],"powerkit_post_featured":[],"class_list":["post-459426","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cardiology","category-education","category-rx-en","category-studies","tag-aficamten","tag-cardiomyopathy","tag-forest","tag-kccq","tag-lvot-en","tag-myosin","tag-nt-probnp","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-16 14:57:44","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":459423,"slug":"cardiomyopathie-hypertrophique-obstructive-symptomatique","post_title":"Cardiomyopathie hypertrophique obstructive symptomatique","href":"https:\/\/medizinonline.com\/fr\/cardiomyopathie-hypertrophique-obstructive-symptomatique\/"},"it_IT":{"locale":"it_IT","id":459417,"slug":"cardiomiopatia-ipertrofica-ostruttiva-sintomatica","post_title":"Cardiomiopatia ipertrofica ostruttiva sintomatica","href":"https:\/\/medizinonline.com\/it\/cardiomiopatia-ipertrofica-ostruttiva-sintomatica\/"},"pt_PT":{"locale":"pt_PT","id":459414,"slug":"cardiomiopatia-hipertrofica-obstrutiva-sintomatica","post_title":"Cardiomiopatia hipertr\u00f3fica obstrutiva sintom\u00e1tica","href":"https:\/\/medizinonline.com\/pt-pt\/cardiomiopatia-hipertrofica-obstrutiva-sintomatica\/"},"es_ES":{"locale":"es_ES","id":459411,"slug":"miocardiopatia-hipertrofica-obstructiva-sintomatica","post_title":"Miocardiopat\u00eda hipertr\u00f3fica obstructiva sintom\u00e1tica","href":"https:\/\/medizinonline.com\/es\/miocardiopatia-hipertrofica-obstructiva-sintomatica\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/459426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=459426"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/459426\/revisions"}],"predecessor-version":[{"id":459428,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/459426\/revisions\/459428"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/459427"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=459426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=459426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=459426"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=459426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}