{"id":460263,"date":"2026-02-10T12:30:00","date_gmt":"2026-02-10T11:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/the-inflammatory-subgroup-of-major-depression\/"},"modified":"2026-02-10T09:32:08","modified_gmt":"2026-02-10T08:32:08","slug":"the-inflammatory-subgroup-of-major-depression","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/the-inflammatory-subgroup-of-major-depression\/","title":{"rendered":"The inflammatory subgroup of major depression"},"content":{"rendered":"\n

Major depression<\/em> remains one of the leading causes of disability and suicidality worldwide. A key reason for the inadequate effectiveness of many treatments is their marked biological and clinical heterogeneity. The available evidence indicates that chronically increased inflammatory activity is a key pathophysiological mechanism in a relevant proportion of those affected. This inflammatory subgroup shows characteristic biomarker profiles, specific symptom clusters, a particular interaction with neurotransmitter systems and a differentiated response to forms of therapy. The precise characterization of this subtype can make a decisive contribution to the further development of targeted, mechanistically based personalized psychiatry. <\/strong><\/p>\n\n

Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich
Jetzt beitreten<\/a><\/div>
Already a member? Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Major depression remains one of the leading causes of disability and suicidality worldwide. A key reason for the inadequate effectiveness of many treatments is their marked biological and clinical heterogeneity….…... <\/p>\n

Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich
Jetzt beitreten<\/a><\/div>
Already a member? Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":460264,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Consequences for pathophysiology, clinic and therapy ","footnotes":""},"category":[11548,11508,11442,11466,11503],"tags":[14999,88054,53495,24085],"powerkit_post_featured":[],"class_list":["post-460263","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-education","category-pharmacology-and-toxicology","category-psychiatry-and-psychotherapy","category-studies","tag-depression-en","tag-inflammatory-phenotype","tag-major-depression-en","tag-suicide","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-07-01 09:03:12","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":460260,"slug":"le-sous-groupe-inflammatoire-de-la-depression-majeure","post_title":"Le sous-groupe inflammatoire de la d\u00e9pression majeure","href":"https:\/\/medizinonline.com\/fr\/le-sous-groupe-inflammatoire-de-la-depression-majeure\/"},"it_IT":{"locale":"it_IT","id":460242,"slug":"il-sottogruppo-infiammatorio-della-depressione-maggiore","post_title":"Il sottogruppo infiammatorio della depressione maggiore","href":"https:\/\/medizinonline.com\/it\/il-sottogruppo-infiammatorio-della-depressione-maggiore\/"},"pt_PT":{"locale":"pt_PT","id":460239,"slug":"o-subgrupo-inflamatorio-da-depressao-major","post_title":"O subgrupo inflamat\u00f3rio da depress\u00e3o major","href":"https:\/\/medizinonline.com\/pt-pt\/o-subgrupo-inflamatorio-da-depressao-major\/"},"es_ES":{"locale":"es_ES","id":460236,"slug":"el-subgrupo-inflamatorio-de-la-depresion-mayor","post_title":"El subgrupo inflamatorio de la depresi\u00f3n mayor","href":"https:\/\/medizinonline.com\/es\/el-subgrupo-inflamatorio-de-la-depresion-mayor\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=460263"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460263\/revisions"}],"predecessor-version":[{"id":460265,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460263\/revisions\/460265"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/460264"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=460263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=460263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=460263"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=460263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}