{"id":460542,"date":"2026-01-24T13:30:00","date_gmt":"2026-01-24T12:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/longevity-brain\/"},"modified":"2026-01-24T14:05:36","modified_gmt":"2026-01-24T13:05:36","slug":"longevity-brain","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/longevity-brain\/","title":{"rendered":"Longevity &amp; Brain"},"content":{"rendered":"\n<p><strong>Cognitive health in old age is not an inevitable fate, but can be influenced to a relevant extent by modifiable factors. The <em>Lancet Commission<\/em> 2024 concludes that a significant proportion of dementia cases are potentially preventable or delayable over the course of a lifetime; the estimated proportion is around 45%. Elevated LDL cholesterol levels and untreated visual impairment are newly highlighted as relevant risk factors. At the same time, randomized trials have shown that structured multidimensional prevention programs can have a beneficial effect on cognitive trajectories, especially in people at increased risk (e.g. U.S. POINTER, <em>JAMA <\/em>2025). Disease-modifying anti-amyloid antibodies are also available for early stages of Alzheimer&#8217;s disease, but their use is subject to clear diagnostic and safety requirements (e.g. lecanemab, <em>NEJM<\/em> 2023; FDA labeling on ARIA risks).    <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Flongevity-brain%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Cognitive health in old age is not an inevitable fate, but can be influenced to a relevant extent by modifiable factors. The Lancet Commission 2024 concludes that a significant proportion&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Flongevity-brain%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":460543,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Neuroprotection, resilience and cognitive health in old age  ","footnotes":""},"category":[11508,11297,11347,11363,11460,11548,11503],"tags":[],"powerkit_post_featured":[],"class_list":["post-460542","post","type-post","status-publish","format-standard","has-post-thumbnail","category-education","category-general-internal-medicine","category-geriatrics","category-neurology","category-prevention-and-health-care","category-rx-en","category-studies","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-18 17:35:01","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":460539,"slug":"longevite-cerveau","post_title":"Longevit\u00e9 &amp; cerveau","href":"https:\/\/medizinonline.com\/fr\/longevite-cerveau\/"},"it_IT":{"locale":"it_IT","id":460536,"slug":"longevita-e-cervello","post_title":"Longevit\u00e0 e cervello","href":"https:\/\/medizinonline.com\/it\/longevita-e-cervello\/"},"pt_PT":{"locale":"pt_PT","id":460533,"slug":"longevidade-e-cerebro","post_title":"Longevidade e c\u00e9rebro","href":"https:\/\/medizinonline.com\/pt-pt\/longevidade-e-cerebro\/"},"es_ES":{"locale":"es_ES","id":460548,"slug":"longevidad-y-cerebro","post_title":"Longevidad y cerebro","href":"https:\/\/medizinonline.com\/es\/longevidad-y-cerebro\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=460542"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460542\/revisions"}],"predecessor-version":[{"id":460544,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460542\/revisions\/460544"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/460543"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=460542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=460542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=460542"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=460542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}