{"id":460572,"date":"2026-02-27T22:19:12","date_gmt":"2026-02-27T21:19:12","guid":{"rendered":"https:\/\/medizinonline.com\/preventive-pharmacology-and-longevity\/"},"modified":"2026-02-27T22:19:21","modified_gmt":"2026-02-27T21:19:21","slug":"preventive-pharmacology-and-longevity","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/preventive-pharmacology-and-longevity\/","title":{"rendered":"Preventive pharmacology and longevity"},"content":{"rendered":"\n<p><strong>In medicine, &#8220;longevity&#8221; is now less anti-ageing marketing than a very specific question of precision prevention: which pharmacological interventions prevent (or delay) cardiometabolic, renal, oncological and functional endpoints &#8211; and therefore plausibly also &#8220;biological ageing&#8221;? The crucial point for physicians is that only part of the longevity discussion is based on hard clinical endpoints (mortality, MACE, HF hospitalization, progression of CKD), while much of it comes from animal models, surrogate markers or small human studies. The following is a strictly evidence-based, practice-oriented classification &#8211; including those substances that were spectacular in the mouse model or are used off-label in parts of the scene.  <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fpreventive-pharmacology-and-longevity%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In medicine, &#8220;longevity&#8221; is now less anti-ageing marketing than a very specific question of precision prevention: which pharmacological interventions prevent (or delay) cardiometabolic, renal, oncological and functional endpoints &#8211; and&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fpreventive-pharmacology-and-longevity%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":460573,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"From statins to metformin  ","footnotes":""},"category":[11359,11508,11384,11396,11442,11460,11548,11503],"tags":[],"powerkit_post_featured":[],"class_list":["post-460572","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cardiology","category-education","category-endocrinology-and-diabetology","category-genetics","category-pharmacology-and-toxicology","category-prevention-and-health-care","category-rx-en","category-studies","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-16 13:08:41","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":460557,"slug":"pharmacologie-preventive-et-longevite","post_title":"Pharmacologie pr\u00e9ventive et long\u00e9vit\u00e9","href":"https:\/\/medizinonline.com\/fr\/pharmacologie-preventive-et-longevite\/"},"it_IT":{"locale":"it_IT","id":460569,"slug":"farmacologia-preventiva-e-longevita","post_title":"Farmacologia preventiva e longevit\u00e0","href":"https:\/\/medizinonline.com\/it\/farmacologia-preventiva-e-longevita\/"},"pt_PT":{"locale":"pt_PT","id":460554,"slug":"farmacologia-preventiva-e-longevidade","post_title":"Farmacologia preventiva e longevidade","href":"https:\/\/medizinonline.com\/pt-pt\/farmacologia-preventiva-e-longevidade\/"},"es_ES":{"locale":"es_ES","id":460566,"slug":"farmacologia-preventiva-y-longevidad","post_title":"Farmacolog\u00eda preventiva y longevidad","href":"https:\/\/medizinonline.com\/es\/farmacologia-preventiva-y-longevidad\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460572","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=460572"}],"version-history":[{"count":2,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460572\/revisions"}],"predecessor-version":[{"id":551188,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460572\/revisions\/551188"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/460573"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=460572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=460572"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=460572"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=460572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}