{"id":460624,"date":"2026-02-18T12:39:09","date_gmt":"2026-02-18T11:39:09","guid":{"rendered":"https:\/\/medizinonline.com\/gut-brain-axis-in-old-age\/"},"modified":"2026-02-18T12:39:18","modified_gmt":"2026-02-18T11:39:18","slug":"gut-brain-axis-in-old-age","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/gut-brain-axis-in-old-age\/","title":{"rendered":"Gut-brain axis in old age"},"content":{"rendered":"\n<p><strong>As we age, the composition and function of the gut microbiome, the integrity of the intestinal barrier and systemic immune regulation change. These changes are closely linked to the concept of &#8220;inflammaging&#8221; &#8211; a chronic, low-grade inflammatory activation that affects several hallmarks of aging, including mitochondrial dysfunction, cell senescence and neuroinflammation. At the level of the gut-brain axis, data are accumulating that microbiome-associated mechanisms can modulate mood, stress processing, cognitive function and the risk of neurodegenerative diseases via immune, neuroendocrine and neuronal signaling pathways.  <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fgut-brain-axis-in-old-age%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>As we age, the composition and function of the gut microbiome, the integrity of the intestinal barrier and systemic immune regulation change. These changes are closely linked to the concept&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fgut-brain-axis-in-old-age%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":460625,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Microbiome, inflammaging and affective\/cognitive health  ","footnotes":""},"category":[11508,11391,11297,11347,11363,11388,11460,11548,11503],"tags":[],"powerkit_post_featured":[],"class_list":["post-460624","post","type-post","status-publish","format-standard","has-post-thumbnail","category-education","category-gastroenterology-and-hepatology","category-general-internal-medicine","category-geriatrics","category-neurology","category-nutrition","category-prevention-and-health-care","category-rx-en","category-studies","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-14 20:19:43","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":460603,"slug":"laxe-intestin-cerveau-chez-les-personnes-agees","post_title":"L'axe intestin-cerveau chez les personnes \u00e2g\u00e9es","href":"https:\/\/medizinonline.com\/fr\/laxe-intestin-cerveau-chez-les-personnes-agees\/"},"it_IT":{"locale":"it_IT","id":460618,"slug":"lasse-intestino-cervello-nella-terza-eta","post_title":"L'asse intestino-cervello nella terza et\u00e0","href":"https:\/\/medizinonline.com\/it\/lasse-intestino-cervello-nella-terza-eta\/"},"pt_PT":{"locale":"pt_PT","id":460621,"slug":"eixo-intestino-cerebro-na-velhice","post_title":"Eixo intestino-c\u00e9rebro na velhice","href":"https:\/\/medizinonline.com\/pt-pt\/eixo-intestino-cerebro-na-velhice\/"},"es_ES":{"locale":"es_ES","id":460615,"slug":"eje-intestino-cerebro-en-la-vejez","post_title":"Eje intestino-cerebro en la vejez","href":"https:\/\/medizinonline.com\/es\/eje-intestino-cerebro-en-la-vejez\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460624","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=460624"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460624\/revisions"}],"predecessor-version":[{"id":460626,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/460624\/revisions\/460626"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/460625"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=460624"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=460624"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=460624"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=460624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}