{"id":550620,"date":"2026-03-15T12:30:00","date_gmt":"2026-03-15T11:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=550620"},"modified":"2026-03-15T12:55:27","modified_gmt":"2026-03-15T11:55:27","slug":"established-and-novel-biologics-the-therapeutic-landscape-is-in-flux","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/established-and-novel-biologics-the-therapeutic-landscape-is-in-flux\/","title":{"rendered":"Established and novel biologics – the therapeutic landscape is in flux"},"content":{"rendered":"\n

Clinically, atopic dermatitis (AD) manifests itself through a polymorphic picture of efflorescences, with pruritus and xerosis in the foreground. In addition to the antibody therapies dupilumab, tralokinumab and lebrikizumab, which target the IL-4\/IL-13 signaling pathway, a fourth biologic, nemolizumab, is now available for the treatment of AD. The latter targets the IL-31 receptor, which mediates non-histaminergic itching. There are also promising findings from clinical studies on anti-OX40(L) antibodies. <\/strong><\/p>\n\n

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Clinically, atopic dermatitis (AD) manifests itself through a polymorphic picture of efflorescences, with pruritus and xerosis in the foreground. In addition to the antibody therapies dupilumab, tralokinumab and lebrikizumab, which……... <\/p>\n

Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich
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Already a member? Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":550621,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Moderate to severe atopic dermatitis ","footnotes":""},"category":[11548,11331,11340,11508,11503],"tags":[65580,88968,59274,12624,12391,13405,16209,82442,88969,88970,12619,82438,85935,65697,13308],"powerkit_post_featured":[],"class_list":["post-550620","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-allergology-and-clinical-immunology","category-dermatology-and-venereology","category-education","category-studies","tag-adtralza-en","tag-anti-ox40l-antibody","tag-antibody-therapy","tag-atopic-dermatitis-en","tag-biologics-en","tag-dupilumab-en","tag-dupixent-en","tag-ebglyss-en","tag-il-31-receptor","tag-il-4-il-13-signaling-pathway","tag-itching","tag-lebrikizumab-en","tag-nemluvio","tag-nemolizumab-en","tag-tralokinumab-en","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-07-13 15:58:54","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":550617,"slug":"biotherapies-etablies-et-nouvelles-le-paysage-therapeutique-evolue","post_title":"Bioth\u00e9rapies \u00e9tablies et nouvelles : le paysage th\u00e9rapeutique \u00e9volue","href":"https:\/\/medizinonline.com\/fr\/biotherapies-etablies-et-nouvelles-le-paysage-therapeutique-evolue\/"},"it_IT":{"locale":"it_IT","id":550614,"slug":"biologici-affermati-e-nuovi-il-panorama-terapeutico-e-in-evoluzione","post_title":"Biologici affermati e nuovi - il panorama terapeutico \u00e8 in evoluzione","href":"https:\/\/medizinonline.com\/it\/biologici-affermati-e-nuovi-il-panorama-terapeutico-e-in-evoluzione\/"},"pt_PT":{"locale":"pt_PT","id":550611,"slug":"biologicos-estabelecidos-e-novos-o-panorama-terapeutico-esta-a-mudar","post_title":"Biol\u00f3gicos estabelecidos e novos - o panorama terap\u00eautico est\u00e1 a mudar","href":"https:\/\/medizinonline.com\/pt-pt\/biologicos-estabelecidos-e-novos-o-panorama-terapeutico-esta-a-mudar\/"},"es_ES":{"locale":"es_ES","id":550608,"slug":"biologicos-establecidos-y-novedosos-el-panorama-terapeutico-esta-en-constante-cambio","post_title":"Biol\u00f3gicos establecidos y novedosos: el panorama terap\u00e9utico est\u00e1 en constante cambio","href":"https:\/\/medizinonline.com\/es\/biologicos-establecidos-y-novedosos-el-panorama-terapeutico-esta-en-constante-cambio\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/550620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=550620"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/550620\/revisions"}],"predecessor-version":[{"id":550622,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/550620\/revisions\/550622"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/550621"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=550620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=550620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=550620"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=550620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}