{"id":550903,"date":"2026-03-28T23:18:27","date_gmt":"2026-03-28T22:18:27","guid":{"rendered":"https:\/\/medizinonline.com\/?p=550903"},"modified":"2026-03-28T23:18:34","modified_gmt":"2026-03-28T22:18:34","slug":"topical-and-systemic-active-ingredients-proven-and-new-therapeutic-approaches","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/topical-and-systemic-active-ingredients-proven-and-new-therapeutic-approaches\/","title":{"rendered":"Topical and systemic active ingredients: proven and new therapeutic approaches"},"content":{"rendered":"\n<p><strong>Several risk factors and triggers are known to contribute to the different clinical manifestations of rosacea by activating or modulating neurovascular or immunological processes. Thanks to advances in research into the factors involved in the pathogenesis, the complexity of the disease is increasingly better understood at the molecular level. This is also reflected in the availability of Phase III data on several drug candidates for rosacea. Some of these innovative active substances have now been approved in the USA.   <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Ftopical-and-systemic-active-ingredients-proven-and-new-therapeutic-approaches%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Several risk factors and triggers are known to contribute to the different clinical manifestations of rosacea by activating or modulating neurovascular or immunological processes. Thanks to advances in research into&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Ftopical-and-systemic-active-ingredients-proven-and-new-therapeutic-approaches%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":550909,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Rosacea - multifaceted and multifactorial  ","footnotes":""},"category":[11340,11508,11406,11442,11548,11503],"tags":[89196,58576,89199,16928,47341,89198,89193,89194,89202,89197,13652,89200,89201,89195,12546],"powerkit_post_featured":[],"class_list":["post-550903","post","type-post","status-publish","format-standard","has-post-thumbnail","category-dermatology-and-venereology","category-education","category-infectiology","category-pharmacology-and-toxicology","category-rx-en","category-studies","tag-brimonidine","tag-doxycycline","tag-immunological-2","tag-ivermectin-en","tag-metronidazole","tag-mirvaso","tag-neurovascular","tag-omiganan","tag-oracea","tag-perilox","tag-rosacea-en","tag-rosalox","tag-soolantra","tag-systemic-active-ingredients","tag-topical-therapy","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-18 18:21:25","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":550895,"slug":"agents-topiques-et-systemiques-approches-therapeutiques-eprouvees-et-nouvelles","post_title":"Agents topiques et syst\u00e9miques : approches th\u00e9rapeutiques \u00e9prouv\u00e9es et nouvelles","href":"https:\/\/medizinonline.com\/fr\/agents-topiques-et-systemiques-approches-therapeutiques-eprouvees-et-nouvelles\/"},"it_IT":{"locale":"it_IT","id":550920,"slug":"principi-attivi-topici-e-sistemici-approcci-terapeutici-collaudati-e-nuovi","post_title":"Principi attivi topici e sistemici: approcci terapeutici collaudati e nuovi","href":"https:\/\/medizinonline.com\/it\/principi-attivi-topici-e-sistemici-approcci-terapeutici-collaudati-e-nuovi\/"},"pt_PT":{"locale":"pt_PT","id":550916,"slug":"principios-activos-topicos-e-sistemicos-abordagens-terapeuticas-comprovadas-e-novas","post_title":"Princ\u00edpios activos t\u00f3picos e sist\u00e9micos: abordagens terap\u00eauticas comprovadas e novas","href":"https:\/\/medizinonline.com\/pt-pt\/principios-activos-topicos-e-sistemicos-abordagens-terapeuticas-comprovadas-e-novas\/"},"es_ES":{"locale":"es_ES","id":550897,"slug":"principios-activos-topicos-y-sistemicos-enfoques-terapeuticos-probados-y-nuevos","post_title":"Principios activos t\u00f3picos y sist\u00e9micos: enfoques terap\u00e9uticos probados y nuevos","href":"https:\/\/medizinonline.com\/es\/principios-activos-topicos-y-sistemicos-enfoques-terapeuticos-probados-y-nuevos\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/550903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=550903"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/550903\/revisions"}],"predecessor-version":[{"id":550910,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/550903\/revisions\/550910"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/550909"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=550903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=550903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=550903"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=550903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}