{"id":551313,"date":"2026-04-04T23:07:01","date_gmt":"2026-04-04T21:07:01","guid":{"rendered":"https:\/\/medizinonline.com\/?p=551313"},"modified":"2026-04-04T23:07:19","modified_gmt":"2026-04-04T21:07:19","slug":"new-findings-on-the-role-of-inflammation-in-pathogenesis","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/new-findings-on-the-role-of-inflammation-in-pathogenesis\/","title":{"rendered":"New findings on the role of inflammation in pathogenesis"},"content":{"rendered":"\n<p><strong>Myelofibrosis is an inflammation-driven systemic disease in which cytokines, fibrosis and clonal evolution are inextricably linked. New data show that the control of inflammation has a decisive influence on the course of the disease. Modern therapies that simultaneously modulate JAK signaling pathways, hepcidin regulation and inflammatory networks mark a real paradigm shift.  <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fnew-findings-on-the-role-of-inflammation-in-pathogenesis%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Myelofibrosis is an inflammation-driven systemic disease in which cytokines, fibrosis and clonal evolution are inextricably linked. New data show that the control of inflammation has a decisive influence on the&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fnew-findings-on-the-role-of-inflammation-in-pathogenesis%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":551316,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Myelofibrosis","footnotes":""},"category":[11508,11353,11370,11548],"tags":[90180,12702,51836,90155,90146,27732,90174,90183,90167,90157,90147,53013,90144,90170,51829,40129,86083,90149,21613,90161,90175,90164,29847,90152],"powerkit_post_featured":[],"class_list":["post-551313","post","type-post","status-publish","format-standard","has-post-thumbnail","category-education","category-hematology","category-oncology","category-rx-en","tag-acvr1-hepcidin-axis","tag-anemia","tag-bone-marrow-fibrosis","tag-calr","tag-clonal-hematopoiesis","tag-cytokines-en","tag-damps","tag-hepcidin","tag-hmgb1","tag-il-1","tag-il-6","tag-il-6-en","tag-jak-stat-signaling-pathway","tag-jak-stat-signaling-pathways","tag-jak2-en","tag-mf-en","tag-momelotinib","tag-mpl","tag-myelofibrosis","tag-proinflammatory-cytokines","tag-s100a8-a9","tag-tgf-","tag-tnf-en","tag-tnf-","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-12 11:42:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":551327,"slug":"nouvelles-connaissances-sur-le-role-de-linflammation-dans-la-pathogenese","post_title":"Nouvelles connaissances sur le r\u00f4le de l'inflammation dans la pathogen\u00e8se","href":"https:\/\/medizinonline.com\/fr\/nouvelles-connaissances-sur-le-role-de-linflammation-dans-la-pathogenese\/"},"it_IT":{"locale":"it_IT","id":551315,"slug":"nuove-scoperte-sul-ruolo-dellinfiammazione-nella-patogenesi","post_title":"Nuove scoperte sul ruolo dell'infiammazione nella patogenesi","href":"https:\/\/medizinonline.com\/it\/nuove-scoperte-sul-ruolo-dellinfiammazione-nella-patogenesi\/"},"pt_PT":{"locale":"pt_PT","id":551324,"slug":"novas-descobertas-sobre-o-papel-da-inflamacao-na-patogenese","post_title":"Novas descobertas sobre o papel da inflama\u00e7\u00e3o na patog\u00e9nese","href":"https:\/\/medizinonline.com\/pt-pt\/novas-descobertas-sobre-o-papel-da-inflamacao-na-patogenese\/"},"es_ES":{"locale":"es_ES","id":551314,"slug":"nuevos-hallazgos-sobre-el-papel-de-la-inflamacion-en-la-patogenesis","post_title":"Nuevos hallazgos sobre el papel de la inflamaci\u00f3n en la patog\u00e9nesis","href":"https:\/\/medizinonline.com\/es\/nuevos-hallazgos-sobre-el-papel-de-la-inflamacion-en-la-patogenesis\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/551313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=551313"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/551313\/revisions"}],"predecessor-version":[{"id":551319,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/551313\/revisions\/551319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/551316"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=551313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=551313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=551313"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=551313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}