{"id":553753,"date":"2026-05-15T23:04:03","date_gmt":"2026-05-15T21:04:03","guid":{"rendered":"https:\/\/medizinonline.com\/?p=553753"},"modified":"2026-05-15T23:04:15","modified_gmt":"2026-05-15T21:04:15","slug":"the-underestimated-cardiovascular-threat","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/the-underestimated-cardiovascular-threat\/","title":{"rendered":"The underestimated cardiovascular threat"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Metabolic-associated steatohepatitis (MASH) was long considered a purely hepatic problem. Today, data from large clinical trials and registries clearly show that cardiovascular disease is the most common cause of death in patients with MASH &#8211; ahead of liver failure and hepatocellular carcinoma. With the FDA approval of resmetirome in March 2024 and semaglutide in August 2025, the therapeutic paradigm has fundamentally changed. Both substances not only address liver histology, but also have favorable effects on the cardiometabolic risk profile. This means for cardiology practice: MASH must be recognized, screened and treated as a cardiovascular risk factor in its own right.    <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fthe-underestimated-cardiovascular-threat%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Metabolic-associated steatohepatitis (MASH) was long considered a purely hepatic problem. Today, data from large clinical trials and registries clearly show that cardiovascular disease is the most common cause of death&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fthe-underestimated-cardiovascular-threat%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":553754,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"MASH and heart health  ","footnotes":""},"category":[11548,11359,11508,11391,11297,11442,11503],"tags":[83694,15143,77508,82940],"powerkit_post_featured":[],"class_list":["post-553753","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-cardiology","category-education","category-gastroenterology-and-hepatology","category-general-internal-medicine","category-pharmacology-and-toxicology","category-studies","tag-mash-en-3","tag-nafld-en","tag-resmetirom-en","tag-steatohepatitis-en","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-20 18:41:34","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":553796,"slug":"la-menace-cardiovasculaire-sous-estimee","post_title":"La menace cardiovasculaire sous-estim\u00e9e","href":"https:\/\/medizinonline.com\/fr\/la-menace-cardiovasculaire-sous-estimee\/"},"it_IT":{"locale":"it_IT","id":553793,"slug":"la-minaccia-cardiovascolare-sottovalutata","post_title":"La minaccia cardiovascolare sottovalutata","href":"https:\/\/medizinonline.com\/it\/la-minaccia-cardiovascolare-sottovalutata\/"},"pt_PT":{"locale":"pt_PT","id":553809,"slug":"a-ameaca-cardiovascular-subestimada","post_title":"A amea\u00e7a cardiovascular subestimada","href":"https:\/\/medizinonline.com\/pt-pt\/a-ameaca-cardiovascular-subestimada\/"},"es_ES":{"locale":"es_ES","id":553803,"slug":"la-subestimada-amenaza-cardiovascular","post_title":"La subestimada amenaza cardiovascular","href":"https:\/\/medizinonline.com\/es\/la-subestimada-amenaza-cardiovascular\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/553753","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=553753"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/553753\/revisions"}],"predecessor-version":[{"id":553755,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/553753\/revisions\/553755"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/553754"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=553753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=553753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=553753"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=553753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}