{"id":554940,"date":"2026-04-16T03:00:00","date_gmt":"2026-04-16T01:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/how-do-myosin-inhibitors-perform-in-different-hcm-phenotypes\/"},"modified":"2026-04-22T16:04:00","modified_gmt":"2026-04-22T14:04:00","slug":"how-do-myosin-inhibitors-perform-in-different-hcm-phenotypes","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/how-do-myosin-inhibitors-perform-in-different-hcm-phenotypes\/","title":{"rendered":"How do myosin inhibitors perform in different HCM phenotypes?"},"content":{"rendered":"\n

Cardiac myosin inhibitors have been developed as a targeted therapeutic option for modulating sarcomere function. While in clinical trials in obstructive hypertrophic cardiomyopathy they brought about a greater improvement in exercise tolerance and symptoms than placebo and beta-blockers, in a recent Phase III trial in non-obstructive phenotypes there were no significant differences in the placebo comparison. <\/strong><\/p>\n\n

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Cardiac myosin inhibitors have been developed as a targeted therapeutic option for modulating sarcomere function. While in clinical trials in obstructive hypertrophic cardiomyopathy they brought about a greater improvement in……... <\/p>\n

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Already a member? Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":554941,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Hypertrophic cardiomyopathies (HCM) ","footnotes":""},"category":[11359,11513,11297,11548,11503],"tags":[87434,29527,34819,91448,91447,76037,91445,91446],"powerkit_post_featured":[],"class_list":["post-554940","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cardiology","category-congress-reports","category-general-internal-medicine","category-rx-en","category-studies","tag-aficamten","tag-beta-blocker-en","tag-hcm-en","tag-hypertrophic-cardiomyopathies","tag-maple-hcm-study","tag-mavacamten-en","tag-myosin-inhibitors","tag-odyssey-hcm-study","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-30 04:16:59","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":554937,"slug":"comment-les-inhibiteurs-de-la-myosine-se-comportent-ils-dans-differents-phenotypes-de-cmh","post_title":"Comment les inhibiteurs de la myosine se comportent-ils dans diff\u00e9rents ph\u00e9notypes de CMH ?","href":"https:\/\/medizinonline.com\/fr\/comment-les-inhibiteurs-de-la-myosine-se-comportent-ils-dans-differents-phenotypes-de-cmh\/"},"it_IT":{"locale":"it_IT","id":554934,"slug":"come-si-comportano-gli-inibitori-della-miosina-nei-diversi-fenotipi-di-hcm","post_title":"Come si comportano gli inibitori della miosina nei diversi fenotipi di HCM?","href":"https:\/\/medizinonline.com\/it\/come-si-comportano-gli-inibitori-della-miosina-nei-diversi-fenotipi-di-hcm\/"},"pt_PT":{"locale":"pt_PT","id":554931,"slug":"como-e-que-os-inibidores-da-miosina-actuam-em-diferentes-fenotipos-de-cmh-hcm","post_title":"Como \u00e9 que os inibidores da miosina actuam em diferentes fen\u00f3tipos de CMH (HCM)?","href":"https:\/\/medizinonline.com\/pt-pt\/como-e-que-os-inibidores-da-miosina-actuam-em-diferentes-fenotipos-de-cmh-hcm\/"},"es_ES":{"locale":"es_ES","id":554955,"slug":"como-actuan-los-inhibidores-de-la-miosina-en-diferentes-fenotipos-de-mch","post_title":"\u00bfC\u00f3mo act\u00faan los inhibidores de la miosina en diferentes fenotipos de MCH?","href":"https:\/\/medizinonline.com\/es\/como-actuan-los-inhibidores-de-la-miosina-en-diferentes-fenotipos-de-mch\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/554940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=554940"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/554940\/revisions"}],"predecessor-version":[{"id":554942,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/554940\/revisions\/554942"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/554941"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=554940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=554940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=554940"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=554940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}