{"id":555111,"date":"2026-04-28T21:33:58","date_gmt":"2026-04-28T19:33:58","guid":{"rendered":"https:\/\/medizinonline.com\/?p=555111"},"modified":"2026-04-28T21:34:07","modified_gmt":"2026-04-28T19:34:07","slug":"targeted-therapy-options-on-the-rise","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/targeted-therapy-options-on-the-rise\/","title":{"rendered":"Targeted therapy options on the rise"},"content":{"rendered":"\n<p><strong>The pathophysiology of prurigo nodularis (PN) is multifactorial and complex, but great progress has recently been made in terms of treatment options. In addition to the monoclonal antibodies dupilumab and nemolizumab approved on the basis of the PRIME\/PRIME2 studies and the OLYMPIA study program, various systemic agents are currently being investigated in phase II and III clinical trials, including several monoclonal antibodies and Janus kinase inhibitors. <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Ftargeted-therapy-options-on-the-rise%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The pathophysiology of prurigo nodularis (PN) is multifactorial and complex, but great progress has recently been made in terms of treatment options. In addition to the monoclonal antibodies dupilumab and&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Ftargeted-therapy-options-on-the-rise%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":555112,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Prurigo nodularis: evidence-based treatment  ","footnotes":""},"category":[11331,11340,11508,11442,11548,11503],"tags":[67753,82458,13405,12619,91544,65697,85937,91542,83458,91543,65684,83457],"powerkit_post_featured":[],"class_list":["post-555111","post","type-post","status-publish","format-standard","has-post-thumbnail","category-allergology-and-clinical-immunology","category-dermatology-and-venereology","category-education","category-pharmacology-and-toxicology","category-rx-en","category-studies","tag-abrocitinib-en","tag-barzolvolimab-en","tag-dupilumab-en","tag-itching","tag-nalbuphin","tag-nemolizumab-en","tag-olympia","tag-opiod-modulators","tag-povorcitinib-en","tag-prime-prime2","tag-prurigo-nodularis-en","tag-vixarelimab-en","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-09 00:03:21","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":555083,"slug":"les-options-therapeutiques-ciblees-gagnent-du-terrain","post_title":"Les options th\u00e9rapeutiques cibl\u00e9es gagnent du terrain","href":"https:\/\/medizinonline.com\/fr\/les-options-therapeutiques-ciblees-gagnent-du-terrain\/"},"it_IT":{"locale":"it_IT","id":555097,"slug":"le-opzioni-di-terapia-mirata-sono-in-aumento","post_title":"Le opzioni di terapia mirata sono in aumento","href":"https:\/\/medizinonline.com\/it\/le-opzioni-di-terapia-mirata-sono-in-aumento\/"},"pt_PT":{"locale":"pt_PT","id":555087,"slug":"as-opcoes-de-terapia-direcionada-estao-a-aumentar","post_title":"As op\u00e7\u00f5es de terapia direcionada est\u00e3o a aumentar","href":"https:\/\/medizinonline.com\/pt-pt\/as-opcoes-de-terapia-direcionada-estao-a-aumentar\/"},"es_ES":{"locale":"es_ES","id":555096,"slug":"aumentan-las-opciones-de-terapia-dirigida","post_title":"Aumentan las opciones de terapia dirigida","href":"https:\/\/medizinonline.com\/es\/aumentan-las-opciones-de-terapia-dirigida\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/555111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=555111"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/555111\/revisions"}],"predecessor-version":[{"id":555114,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/555111\/revisions\/555114"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/555112"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=555111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=555111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=555111"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=555111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}