{"id":555961,"date":"2026-05-29T12:30:00","date_gmt":"2026-05-29T10:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=555961"},"modified":"2026-05-29T14:19:25","modified_gmt":"2026-05-29T12:19:25","slug":"modulate-cortical-excitatory-activity-with-diazepam","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/modulate-cortical-excitatory-activity-with-diazepam\/","title":{"rendered":"Modulate cortical excitatory activity with diazepam"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Individuals at <em> clinical high risk for psych <\/em>osis (CHRp) have an estimated 27% chance of developing a psychotic disorder within three years, but there are currently no established preventive pharmacological strategies. Diazepam, a positive allosteric modulator of GABAA receptors, has been shown in experimental models to attenuate behavioral changes associated with psychosis. <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fmodulate-cortical-excitatory-activity-with-diazepam%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Individuals at clinical high risk for psych osis (CHRp) have an estimated 27% chance of developing a psychotic disorder within three years, but there are currently no established preventive pharmacological&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fmodulate-cortical-excitatory-activity-with-diazepam%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":555963,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Risk of psychosis","footnotes":""},"category":[11548,11508,11442,11466,11503],"tags":[91929,85619,91928,91930,30436,91931],"powerkit_post_featured":[],"class_list":["post-555961","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-education","category-pharmacology-and-toxicology","category-psychiatry-and-psychotherapy","category-studies","tag-cortical-excitatory-activity","tag-diazepam","tag-gabaa-receptor","tag-neuronal-excitation","tag-psychoses","tag-psychotic-disorders","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-30 01:35:43","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":555894,"slug":"moduler-lactivite-excitatrice-corticale-avec-le-diazepam","post_title":"Moduler l'activit\u00e9 excitatrice corticale avec le diaz\u00e9pam","href":"https:\/\/medizinonline.com\/fr\/moduler-lactivite-excitatrice-corticale-avec-le-diazepam\/"},"it_IT":{"locale":"it_IT","id":555957,"slug":"modulare-lattivita-eccitatoria-corticale-con-diazepam","post_title":"Modulare l'attivit\u00e0 eccitatoria corticale con diazepam","href":"https:\/\/medizinonline.com\/it\/modulare-lattivita-eccitatoria-corticale-con-diazepam\/"},"pt_PT":{"locale":"pt_PT","id":555908,"slug":"modular-a-atividade-excitatoria-cortical-com-diazepam","post_title":"Modular a atividade excitat\u00f3ria cortical com diazepam","href":"https:\/\/medizinonline.com\/pt-pt\/modular-a-atividade-excitatoria-cortical-com-diazepam\/"},"es_ES":{"locale":"es_ES","id":555953,"slug":"modular-la-actividad-excitatoria-cortical-con-diazepam","post_title":"Modular la actividad excitatoria cortical con diazepam","href":"https:\/\/medizinonline.com\/es\/modular-la-actividad-excitatoria-cortical-con-diazepam\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/555961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=555961"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/555961\/revisions"}],"predecessor-version":[{"id":555964,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/555961\/revisions\/555964"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/555963"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=555961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=555961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=555961"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=555961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}