{"id":555978,"date":"2026-06-09T22:06:08","date_gmt":"2026-06-09T20:06:08","guid":{"rendered":"https:\/\/medizinonline.com\/?p=555978"},"modified":"2026-06-09T22:06:14","modified_gmt":"2026-06-09T20:06:14","slug":"esketamine-nasal-spray-as-monotherapy-new-for-treatment-resistant-depression","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/esketamine-nasal-spray-as-monotherapy-new-for-treatment-resistant-depression\/","title":{"rendered":"Esketamine nasal spray as monotherapy? New for treatment-resistant depression"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Despite a variety of approved antidepressant treatments, major depressive disorder (MDD) remains one of the leading causes of disability worldwide and has been shown to shorten the life expectancy of affected patients. Intranasal esketamine has been shown in a study to be significantly effective even without concomitant oral antidepressants, offering an important alternative for patients with intolerance or lack of response to conventional antidepressants. <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fesketamine-nasal-spray-as-monotherapy-new-for-treatment-resistant-depression%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Despite a variety of approved antidepressant treatments, major depressive disorder (MDD) remains one of the leading causes of disability worldwide and has been shown to shorten the life expectancy of&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fesketamine-nasal-spray-as-monotherapy-new-for-treatment-resistant-depression%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":555979,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Treatment resistant depression","footnotes":""},"category":[11548,11508,11297,11427,11442,11466,11503],"tags":[46835,23009,91938,91939,76621],"powerkit_post_featured":[],"class_list":["post-555978","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-education","category-general-internal-medicine","category-orl-en","category-pharmacology-and-toxicology","category-psychiatry-and-psychotherapy","category-studies","tag-antidepressant","tag-esketamine","tag-sd","tag-severe-depression","tag-treatment-resistant-depression","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-07-12 12:14:44","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":555928,"slug":"lesketamine-en-spray-nasal-en-monotherapie-du-nouveau-dans-la-depression-resistante-aux-traitements","post_title":"L'esk\u00e9tamine en spray nasal en monoth\u00e9rapie ? Du nouveau dans la d\u00e9pression r\u00e9sistante aux traitements","href":"https:\/\/medizinonline.com\/fr\/lesketamine-en-spray-nasal-en-monotherapie-du-nouveau-dans-la-depression-resistante-aux-traitements\/"},"it_IT":{"locale":"it_IT","id":555871,"slug":"esketamina-spray-nasale-come-monoterapia-novita-per-la-depressione-resistente-al-trattamento","post_title":"Esketamina spray nasale come monoterapia? Novit\u00e0 per la depressione resistente al trattamento","href":"https:\/\/medizinonline.com\/it\/esketamina-spray-nasale-come-monoterapia-novita-per-la-depressione-resistente-al-trattamento\/"},"pt_PT":{"locale":"pt_PT","id":555924,"slug":"spray-nasal-de-esketamina-como-monoterapia-novo-para-a-depressao-resistente-ao-tratamento","post_title":"Spray nasal de esketamina como monoterapia? Novo para a depress\u00e3o resistente ao tratamento","href":"https:\/\/medizinonline.com\/pt-pt\/spray-nasal-de-esketamina-como-monoterapia-novo-para-a-depressao-resistente-ao-tratamento\/"},"es_ES":{"locale":"es_ES","id":555974,"slug":"esketamina-en-aerosol-nasal-como-monoterapia-novedades-para-la-depresion-resistente-al-tratamiento","post_title":"\u00bfEsketamina en aerosol nasal como monoterapia? Novedades para la depresi\u00f3n resistente al tratamiento","href":"https:\/\/medizinonline.com\/es\/esketamina-en-aerosol-nasal-como-monoterapia-novedades-para-la-depresion-resistente-al-tratamiento\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/555978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=555978"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/555978\/revisions"}],"predecessor-version":[{"id":555981,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/555978\/revisions\/555981"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/555979"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=555978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=555978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=555978"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=555978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}