{"id":556720,"date":"2026-06-04T22:45:51","date_gmt":"2026-06-04T20:45:51","guid":{"rendered":"https:\/\/medizinonline.com\/?p=556720"},"modified":"2026-06-01T11:05:22","modified_gmt":"2026-06-01T09:05:22","slug":"destiny-breast11-neoadjuvant-t-dxd-without-anthracyclines","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/destiny-breast11-neoadjuvant-t-dxd-without-anthracyclines\/","title":{"rendered":"DESTINY-Breast11 &#8211; neoadjuvant T-DXd without anthracyclines"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>The phase III DESTINY-Breast11 trial shows that neoadjuvant trastuzumab deruxtecan (T-DXd) could provide an anthracycline-free treatment option for HER2-positive early breast cancer. The results suggest an effective and better tolerated alternative to standard anthracycline-containing regimens. <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fdestiny-breast11-neoadjuvant-t-dxd-without-anthracyclines%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The phase III DESTINY-Breast11 trial shows that neoadjuvant trastuzumab deruxtecan (T-DXd) could provide an anthracycline-free treatment option for HER2-positive early breast cancer. The results suggest an effective and better tolerated&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fdestiny-breast11-neoadjuvant-t-dxd-without-anthracyclines%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":556723,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"HER2+ early breast cancer","footnotes":"","_members_access_role":[],"_members_access_error":""},"category":[11548,11508,11400,11370,11503],"tags":[92954,90851,92971,92974,90850,92980,13554,92976,92985,92983,92958,92948,92979,92972,92970,92975,16452,92962,92952,92960,92304,92977,92966,92969,54787,92982,92968,72826,13568,23583,92984,92987,92513,57773,92950,92978,92981,92964,92986,92973,92956],"powerkit_post_featured":[],"class_list":["post-556720","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-education","category-gynecology","category-oncology","category-studies","tag-adc-breast-cancer","tag-adc-therapy","tag-anthracycline-free-approach","tag-anthracycline-free-treatment-regimen","tag-antibody-drug-conjugate-2","tag-brain-metastases-breast-cancer","tag-breast-cancer-en","tag-cardiac-toxicity","tag-cardiotoxicity-anthracyclines","tag-ddac-thp","tag-destiny-breast03","tag-destiny-breast11","tag-dose-condensed-anthracycline-treatment-regimen","tag-efs","tag-event-free-survival","tag-hematologic-toxicity","tag-her2-en","tag-her2-positive-breast-cancer-2","tag-her2-positive-early-breast-cancer","tag-her2-targeted-antibodies","tag-her2-targeted-therapy","tag-leptomeningeal-metastases","tag-neoadjuvant-t-dxd","tag-neoadjuvant-therapy-her2-positive","tag-overall-survival","tag-paclitaxel-plus-dual-her2-blockade","tag-pathological-complete-remission","tag-pcr-rate-en","tag-pfs-en","tag-progression-free-survival","tag-severe-neutropenia","tag-st-gallen-consensus","tag-swiss-oncology","tag-t-dm1-en","tag-t-dxd","tag-t-dxd-anthracycline-containing-therapy","tag-t-dxd-effectiveness","tag-t-dxd-monotherapy","tag-t-dxd-security","tag-thp-therapy","tag-trastuzumab-deruxtecan","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-08-08 15:06:54","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":556648,"slug":"destiny-breast11-t-dxd-neoadjuvant-sans-anthracyclines","post_title":"DESTINY-Breast11 - 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