{"id":558482,"date":"2026-06-18T00:30:00","date_gmt":"2026-06-17T22:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=558482"},"modified":"2026-06-18T06:41:21","modified_gmt":"2026-06-18T04:41:21","slug":"why-is-it-so-hard-to-lose-weight","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/why-is-it-so-hard-to-lose-weight\/","title":{"rendered":"Why is it so hard to lose weight?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Obesity is the most common chronic disease in Western societies, with serious metabolic, cardiovascular, and psychosocial consequences. The therapeutic landscape has changed fundamentally: new-generation GLP-1 agonists achieve weight loss that, just a few years ago, was reserved solely for bariatric surgery. This presents physicians with a clear task: to understand obesity as a biologically based chronic disease and to treat it accordingly.  <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fwhy-is-it-so-hard-to-lose-weight%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Obesity is the most common chronic disease in Western societies, with serious metabolic, cardiovascular, and psychosocial consequences. The therapeutic landscape has changed fundamentally: new-generation GLP-1 agonists achieve weight loss that,&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fwhy-is-it-so-hard-to-lose-weight%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":558484,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"The Brain and the Motivation to Eat","footnotes":""},"category":[11548,22615,11384,11297,11388,11442,11460,11466,11503],"tags":[94397,11655,74206,94393,94394,12390,94398,23859,16079],"powerkit_post_featured":[],"class_list":["post-558482","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-cme-continuing-education","category-endocrinology-and-diabetology","category-general-internal-medicine","category-nutrition","category-pharmacology-and-toxicology","category-prevention-and-health-care","category-psychiatry-and-psychotherapy","category-studies","tag-counter-regulation","tag-diabetes-en","tag-glp1-ra-en","tag-hypothalamic-regulatory-circuits","tag-hypothalamus","tag-obesity","tag-reward-system","tag-slimming","tag-weight-reduction","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-29 00:54:44","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":558488,"slug":"pourquoi-est-il-si-difficile-de-perdre-du-poids","post_title":"Pourquoi est-il si difficile de perdre du poids ?","href":"https:\/\/medizinonline.com\/fr\/pourquoi-est-il-si-difficile-de-perdre-du-poids\/"},"it_IT":{"locale":"it_IT","id":558494,"slug":"perche-e-cosi-difficile-dimagrire","post_title":"Perch\u00e9 \u00e8 cos\u00ec difficile dimagrire?","href":"https:\/\/medizinonline.com\/it\/perche-e-cosi-difficile-dimagrire\/"},"pt_PT":{"locale":"pt_PT","id":558499,"slug":"por-que-razao-e-tao-dificil-perder-peso","post_title":"Por que raz\u00e3o \u00e9 t\u00e3o dif\u00edcil perder peso?","href":"https:\/\/medizinonline.com\/pt-pt\/por-que-razao-e-tao-dificil-perder-peso\/"},"es_ES":{"locale":"es_ES","id":558502,"slug":"por-que-resulta-tan-dificil-adelgazar","post_title":"\u00bfPor qu\u00e9 resulta tan dif\u00edcil adelgazar?","href":"https:\/\/medizinonline.com\/es\/por-que-resulta-tan-dificil-adelgazar\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/558482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=558482"}],"version-history":[{"count":3,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/558482\/revisions"}],"predecessor-version":[{"id":558802,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/558482\/revisions\/558802"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/558484"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=558482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=558482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=558482"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=558482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}