{"id":558622,"date":"2026-07-09T23:34:44","date_gmt":"2026-07-09T21:34:44","guid":{"rendered":"https:\/\/medizinonline.com\/?p=558622"},"modified":"2026-06-18T14:18:34","modified_gmt":"2026-06-18T12:18:34","slug":"gene-environment-interactions-polygenic-or-monogenic-determinants","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/gene-environment-interactions-polygenic-or-monogenic-determinants\/","title":{"rendered":"Gene-Environment Interactions: Polygenic or Monogenic Determinants?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>In the context of precision medicine, a differentiated approach to the diagnosis of obesity provides an essential foundation for implementing improved strategies for prevention, treatment, and prognosis. Obesity is often caused by a polygenic disorder of energy regulation, but there are also rare monogenic and syndromic forms of obesity that arise as early as infancy due to a lack of satiety. Like other chronic diseases, obesity requires long-term medical care\u2014a multimodal treatment approach is most likely to be successful.    <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fgene-environment-interactions-polygenic-or-monogenic-determinants%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In the context of precision medicine, a differentiated approach to the diagnosis of obesity provides an essential foundation for implementing improved strategies for prevention, treatment, and prognosis. Obesity is often&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fgene-environment-interactions-polygenic-or-monogenic-determinants%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":558625,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Obesity in Children and Adolescents","footnotes":""},"category":[11548,11508,11297,11396,11388,11437],"tags":[66577,94585,30880,94594,94587,18544,94590,22153,12390,94591,94583,94595,67596,12312,77168,17444,94584,12530,77169],"powerkit_post_featured":[],"class_list":["post-558622","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-education","category-general-internal-medicine","category-genetics","category-nutrition","category-pediatrics","tag-childhood-and-adolescence","tag-energy-regulation","tag-forecast-en","tag-gene-environment-interactions","tag-imcivree","tag-liraglutide","tag-monogenetic-determinants","tag-multimodal-treatment","tag-obesity","tag-obesity-diagnostics","tag-orlistat","tag-polygenic-determinants","tag-precision-medicine","tag-prevention-en","tag-saxenda-en","tag-semaglutide-en-2","tag-setmelanotide","tag-treatment","tag-wegovy-en","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-07-20 05:48:50","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":558631,"slug":"interactions-genes-environnement-determinants-polygeniques-ou-monogeniques","post_title":"Interactions g\u00e8nes-environnement : d\u00e9terminants polyg\u00e9niques ou monog\u00e9niques ?","href":"https:\/\/medizinonline.com\/fr\/interactions-genes-environnement-determinants-polygeniques-ou-monogeniques\/"},"it_IT":{"locale":"it_IT","id":558641,"slug":"interazioni-gene-ambiente-determinanti-poligenici-o-monogenici","post_title":"Interazioni gene-ambiente: determinanti poligenici o monogenici?","href":"https:\/\/medizinonline.com\/it\/interazioni-gene-ambiente-determinanti-poligenici-o-monogenici\/"},"pt_PT":{"locale":"pt_PT","id":558654,"slug":"interacoes-genico-ambientais-determinantes-poligenicos-ou-monogenicos","post_title":"Intera\u00e7\u00f5es g\u00e9nico-ambientais: determinantes polig\u00e9nicos ou monog\u00e9nicos?","href":"https:\/\/medizinonline.com\/pt-pt\/interacoes-genico-ambientais-determinantes-poligenicos-ou-monogenicos\/"},"es_ES":{"locale":"es_ES","id":558602,"slug":"interacciones-gen-ambiente-determinantes-poligenicos-o-monogenicos","post_title":"Interacciones gen-ambiente: \u00bfdeterminantes polig\u00e9nicos o monog\u00e9nicos?","href":"https:\/\/medizinonline.com\/es\/interacciones-gen-ambiente-determinantes-poligenicos-o-monogenicos\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/558622","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=558622"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/558622\/revisions"}],"predecessor-version":[{"id":558947,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/558622\/revisions\/558947"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/558625"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=558622"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=558622"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=558622"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=558622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}