{"id":561202,"date":"2026-08-10T12:30:00","date_gmt":"2026-08-10T10:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=561202"},"modified":"2026-08-10T13:26:20","modified_gmt":"2026-08-10T11:26:20","slug":"intracrine-and-metabolic-tumor-adaptation-under-androgen-deprivation","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/intracrine-and-metabolic-tumor-adaptation-under-androgen-deprivation\/","title":{"rendered":"Intracrine and Metabolic Tumor Adaptation Under Androgen Deprivation"},"content":{"rendered":"\n

Androgen deprivation therapy (ADT) remains a cornerstone of prostate cancer treatment. It slows tumor growth but also triggers complex intracellular and metabolic response pathways. These tumor adaptations, which significantly influence the course of the disease, open up new possibilities for personalized treatment approaches. <\/strong><\/p>\n\n

Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich
Jetzt beitreten<\/a><\/div>
Already a member? Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Androgen deprivation therapy (ADT) remains a cornerstone of prostate cancer treatment. It slows tumor growth but also triggers complex intracellular and metabolic response pathways. These tumor adaptations, which significantly influence……... <\/p>\n

Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich
Jetzt beitreten<\/a><\/div>
Already a member? Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":561205,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Prostate Cancer ","footnotes":"","_members_access_role":[],"_members_access_error":""},"category":[11548,11508,11370,11503,11490],"tags":[96535,96606,96542,96571,96611,96620,96576,96561,96624,96616,96625,96549,96590,96532,96621,96593,96615,96559,96608,96589,96538,96597,96603,96552,96613,96605,96544,96609,96612,96568,96614,17927,96619,96584,96546,96583,96599,96618,96556,96617,96622,96623,96610,96578,96572,96564,96607],"powerkit_post_featured":[],"class_list":["post-561202","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-education","category-oncology","category-studies","category-urology","tag-androgen-deprivation-therapy-adt","tag-ar-damage-resistance","tag-ar-signaling-pathway-in-prostate-cancer","tag-beta-blockers-and-prostate-cancer","tag-effect-of-beta-blockers-on-response-to-adt","tag-effect-of-green-tea-catechins-on-the-ar-signaling-pathway-and-metabolic-reprogramming","tag-green-tea-catechins-and-prostate-cancer","tag-hypoxia-mir-135b-5p","tag-hypoxia-induced-mir-135b-5p-mediated-neuroendocrine-transdifferentiation","tag-hypoxia-induced-tumor-programs","tag-integration-of-adaptive-tumor-programs-into-treatment-decisions-by-swiss-tumor-boards","tag-integrative-pathology-of-prostate-cancer","tag-interdisciplinary-tumor-boards-in-switzerland-adt-resistance-mechanisms-prostate-cancer","tag-intracellular-androgen-synthesis","tag-intracellular-androgen-synthesis-as-a-resistance-mechanism-and-vitamin-d-dependent-modulation","tag-intracrine-activity-during-adt","tag-liquid-biopsies-for-the-early-detection-of-intracrine-and-neuroendocrine-tumor-programs","tag-liquid-biopsy-for-prostate-cancer","tag-liquid-biopsy-for-resistance-detection","tag-metabolic-reprogramming-of-prostate-cancer","tag-metabolic-tumor-adaptation","tag-molecular-tests-for-prostate-cancer","tag-mpmri-and-psma-pet-for-risk-stratification","tag-mpmri-for-prostate-cancer","tag-multimodal-diagnostics-for-assessing-adaptive-tumor-activity","tag-neuroendocrine-differentiation-in-prostate-cancer","tag-neuroendocrine-transdifferentiation-in-prostate-cancer","tag-plant-based-modulators-adt-effect","tag-platinum-based-therapy-for-ar-independent-tumors","tag-platinum-based-therapy-for-prostate-cancer","tag-preclinical-inhibition-of-the-srebp-axis-by-xanthohumol","tag-prostate-cancer","tag-prostate-cancer-care-in-switzerland-intracrine-and-metabolic-tumor-adaptation-under-androgen-deprivation-in-prostate-cancer","tag-prostate-cancer-in-switzerland","tag-psma-pet-diagnostics","tag-resistance-mechanisms-in-adt","tag-srebp-axis-and-lipid-metabolism","tag-srebp-regulated-lipid-biosynthesis-as-a-therapeutic-target","tag-srebp-lipid-biosynthesis-prostate-cancer","tag-the-importance-of-mpmri-and-psma-pet-for-resistance-stratification","tag-the-yap1-npm1-myc-axis-as-a-driver-of-proliferative-and-ar-independent-programs","tag-use-of-platinum-based-therapies-for-neuroendocrine-and-ar-independent-tumor-components","tag-vitamin-d-modulation-of-intracrine-androgens","tag-vitamin-d-dependent-intracellular-modulation","tag-xanthohumol-and-prostate-cancer","tag-yap1-npm1-myc-axis","tag-yap1-npm1-and-myc-signaling-network","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-08-23 15:34:33","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":561209,"slug":"adaptation-intracrine-et-metabolique-des-tumeurs-sous-privation-androgenique","post_title":"Adaptation intracrine et m\u00e9tabolique des tumeurs sous privation androg\u00e9nique","href":"https:\/\/medizinonline.com\/fr\/adaptation-intracrine-et-metabolique-des-tumeurs-sous-privation-androgenique\/"},"it_IT":{"locale":"it_IT","id":561225,"slug":"adattamento-tumorale-intracrino-e-metabolico-in-condizioni-di-deprivazione-androgenica","post_title":"Adattamento tumorale intracrino e metabolico in condizioni di deprivazione androgenica","href":"https:\/\/medizinonline.com\/it\/adattamento-tumorale-intracrino-e-metabolico-in-condizioni-di-deprivazione-androgenica\/"},"pt_PT":{"locale":"pt_PT","id":561232,"slug":"adaptacao-tumoral-intracriniana-e-metabolica-sob-privacao-androgenica","post_title":"Adapta\u00e7\u00e3o tumoral intracriniana e metab\u00f3lica sob priva\u00e7\u00e3o androg\u00e9nica","href":"https:\/\/medizinonline.com\/pt-pt\/adaptacao-tumoral-intracriniana-e-metabolica-sob-privacao-androgenica\/"},"es_ES":{"locale":"es_ES","id":561211,"slug":"adaptacion-tumoral-intracrina-y-metabolica-bajo-privacion-de-androgenos","post_title":"Adaptaci\u00f3n tumoral intracrina y metab\u00f3lica bajo privaci\u00f3n de andr\u00f3genos","href":"https:\/\/medizinonline.com\/es\/adaptacion-tumoral-intracrina-y-metabolica-bajo-privacion-de-androgenos\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/561202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=561202"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/561202\/revisions"}],"predecessor-version":[{"id":561208,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/561202\/revisions\/561208"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/561205"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=561202"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=561202"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=561202"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=561202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}