{"id":561397,"date":"2026-08-17T21:34:30","date_gmt":"2026-08-17T19:34:30","guid":{"rendered":"https:\/\/medizinonline.com\/?p=561397"},"modified":"2026-07-15T13:41:24","modified_gmt":"2026-07-15T11:41:24","slug":"orofacial-manifestations-of-phelan-mcdermid-syndrome","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/orofacial-manifestations-of-phelan-mcdermid-syndrome\/","title":{"rendered":"Orofacial Manifestations of Phelan-McDermid Syndrome"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Phelan-McDermid syndrome is a rare genetic disorder primarily caused by deletions or structural changes in chromosome 22q13. In a publication from 2025, De Falco et al. described the first documented case of unilateral facial lymphedema associated with Phelan-McDermid syndrome. The patient was referred for evaluation due to developmental delays and pronounced swelling on the right side of her face.   <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Forofacial-manifestations-of-phelan-mcdermid-syndrome%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Phelan-McDermid syndrome is a rare genetic disorder primarily caused by deletions or structural changes in chromosome 22q13. In a publication from 2025, De Falco et al. described the first documented&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Forofacial-manifestations-of-phelan-mcdermid-syndrome%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":561402,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Case study","footnotes":"","_members_access_role":[],"_members_access_error":""},"category":[11548,11520,11508,11297,11396,11437],"tags":[22745,13365,98516,98518,29295,98514,98515,98511,98517,16539],"powerkit_post_featured":[],"class_list":["post-561397","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-cases-en","category-education","category-general-internal-medicine","category-genetics","category-pediatrics","tag-case-study","tag-casuistry","tag-chromosome-22q13","tag-facial-lymphedema","tag-lymphedema","tag-manifestations","tag-orofacial","tag-phelan-mcdermid","tag-phelan-mcdermid-syndrome","tag-symptoms","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-09-06 18:58:36","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/561397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=561397"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/561397\/revisions"}],"predecessor-version":[{"id":561403,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/561397\/revisions\/561403"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/561402"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=561397"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=561397"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=561397"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=561397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}