{"id":563765,"date":"2026-09-22T12:30:00","date_gmt":"2026-09-22T10:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=563765"},"modified":"2026-09-22T13:06:03","modified_gmt":"2026-09-22T11:06:03","slug":"interleukin-blockade-or-ox40-l-inhibition","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/interleukin-blockade-or-ox40-l-inhibition\/","title":{"rendered":"Interleukin blockade or OX40-(L) inhibition?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>The pathogenesis of atopic dermatitis (AD) involves a complex cascade that occurs at various levels. Immunomodulatory antibody therapies have been developed for the treatment of moderate-to-severe AD; these therapies interfere with the inflammatory process in various ways. In addition to biologics that target interleukin(IL)-31R-\u03b1, IL-4R-\u03b1, or selectively against IL-13, clinical trials are currently investigating the effects of monoclonal antibodies that target the OX40-OX40L signaling pathway.<\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Finterleukin-blockade-or-ox40-l-inhibition%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The pathogenesis of atopic dermatitis (AD) involves a complex cascade that occurs at various levels. Immunomodulatory antibody therapies have been developed for the treatment of moderate-to-severe AD; these therapies interfere&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Finterleukin-blockade-or-ox40-l-inhibition%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":563768,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Atopic Dermatitis: Precisely Targeting Immunological Targets","footnotes":"","_members_access_role":[],"_members_access_error":""},"category":[11548,11331,11340,11508,11503],"tags":[99967,82445,84914,82443,13405,99954,99955,82438,99965,65697,99960,99958,99962,99953,99966,99963,13308],"powerkit_post_featured":[],"class_list":["post-563765","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-allergology-and-clinical-immunology","category-dermatology-and-venereology","category-education","category-studies","tag-adjoin","tag-advocate-en","tag-amlitelimab-en","tag-arcadia-en","tag-dupilumab-en","tag-ecztra","tag-interleukin-blockade","tag-lebrikizumab-en","tag-liberty-ad-preschool","tag-nemolizumab-en","tag-ox40-l-inhibition","tag-ox40-ox40l-signal-path","tag-rocatinlimab","tag-rocket","tag-stapokibart","tag-stream-ad","tag-tralokinumab-en","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-09-29 14:31:04","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":563809,"slug":"blocage-de-linterleukine-ou-inhibition-de-lox40-l","post_title":"Blocage de l'interleukine ou inhibition de l'OX40-(L) ?","href":"https:\/\/medizinonline.com\/fr\/blocage-de-linterleukine-ou-inhibition-de-lox40-l\/"},"it_IT":{"locale":"it_IT","id":563820,"slug":"blocco-dellinterleuchina-o-inibizione-dellox40-l","post_title":"Blocco dell\u2019interleuchina o inibizione dell\u2019OX40-(L)?","href":"https:\/\/medizinonline.com\/it\/blocco-dellinterleuchina-o-inibizione-dellox40-l\/"},"pt_PT":{"locale":"pt_PT","id":563832,"slug":"bloqueio-da-interleucina-ou-inibicao-da-ox40-l","post_title":"Bloqueio da interleucina ou inibi\u00e7\u00e3o da OX40-(L)?","href":"https:\/\/medizinonline.com\/pt-pt\/bloqueio-da-interleucina-ou-inibicao-da-ox40-l\/"},"es_ES":{"locale":"es_ES","id":563848,"slug":"bloqueo-de-la-interleucina-o-inhibicion-de-ox40-l","post_title":"\u00bfBloqueo de la interleucina o inhibici\u00f3n de OX40-(L)?","href":"https:\/\/medizinonline.com\/es\/bloqueo-de-la-interleucina-o-inhibicion-de-ox40-l\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/563765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=563765"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/563765\/revisions"}],"predecessor-version":[{"id":563771,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/563765\/revisions\/563771"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/563768"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=563765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=563765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=563765"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=563765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}