{"id":563773,"date":"2026-09-07T00:30:00","date_gmt":"2026-09-06T22:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=563773"},"modified":"2026-09-07T07:48:11","modified_gmt":"2026-09-07T05:48:11","slug":"dariers-disease-also-known-as-follicular-keratosis-update-2026","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/dariers-disease-also-known-as-follicular-keratosis-update-2026\/","title":{"rendered":"Darier&#8217;s Disease, also known as Follicular Keratosis \u2013 Update 2026"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Darier&#8217;s disease is caused by pathogenic variants in the ATP2A2 gene. Advances in our understanding of its pathophysiology have paved the way for the development of innovative therapeutic approaches, but further research is needed to optimize patient outcomes. This is also reflected in the establishment of the <em>International Task Force for Darier\u2019s Disease<\/em> (DD-ITF) in 2025. For patients with severe or refractory disease, oral retinoids are still considered the first-line systemic therapy, but there are an increasing number of case reports documenting the successful use of anti-inflammatory immunomodulatory therapies (JAK inhibitors, biologics). This suggests that complex inflammatory processes are involved in the pathogenesis.<\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fdariers-disease-also-known-as-follicular-keratosis-update-2026%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Darier&#8217;s disease is caused by pathogenic variants in the ATP2A2 gene. Advances in our understanding of its pathophysiology have paved the way for the development of innovative therapeutic approaches, but&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fdariers-disease-also-known-as-follicular-keratosis-update-2026%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":563775,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Rare Genodermatoses: From Diagnosis to Treatment","footnotes":"","_members_access_role":[],"_members_access_error":""},"category":[22615,11520,11340,11442,11548,11503],"tags":[99970,49182,12391,99974,99974,13947,99969,29523,69694,99972,99973,65710,65710,41171,41171,78052,31492],"powerkit_post_featured":[],"class_list":["post-563773","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cme-continuing-education","category-cases-en","category-dermatology-and-venereology","category-pharmacology-and-toxicology","category-rx-en","category-studies","tag-atp2a2-gene","tag-biologics-en-2","tag-biologics-en","tag-dd-itf","tag-diagnostics","tag-follicular-keratosis","tag-genodermatoses","tag-immunomodulatory-therapies","tag-innovative-treatment-approaches","tag-international-task-force-for-dariers-disease","tag-jak-i-en","tag-morbus-darier-en","tag-oral-retinoids","tag-pathogenesis","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-09-14 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2026","href":"https:\/\/medizinonline.com\/it\/malattia-di-darier-nota-anche-come-cheratosi-follicolare-aggiornamento-2026\/"},"pt_PT":{"locale":"pt_PT","id":563800,"slug":"doenca-de-darier-tambem-conhecida-como-queratose-folicular-atualizacao-de-2026","post_title":"Doen\u00e7a de Darier, tamb\u00e9m conhecida como queratose folicular \u2013 Atualiza\u00e7\u00e3o de 2026","href":"https:\/\/medizinonline.com\/pt-pt\/doenca-de-darier-tambem-conhecida-como-queratose-folicular-atualizacao-de-2026\/"},"es_ES":{"locale":"es_ES","id":563766,"slug":"enfermedad-de-darier-tambien-conocida-como-queratosis-folicular-actualizacion-de-2026","post_title":"Enfermedad de Darier, tambi\u00e9n conocida como queratosis folicular \u2013 Actualizaci\u00f3n de 2026","href":"https:\/\/medizinonline.com\/es\/enfermedad-de-darier-tambien-conocida-como-queratosis-folicular-actualizacion-de-2026\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/563773","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=563773"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/563773\/revisions"}],"predecessor-version":[{"id":563778,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/563773\/revisions\/563778"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/563775"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=563773"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=563773"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=563773"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=563773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}