{"id":564145,"date":"2026-09-25T12:30:00","date_gmt":"2026-09-25T10:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=564145"},"modified":"2026-09-04T09:31:32","modified_gmt":"2026-09-04T07:31:32","slug":"topically-applied-small-molecules-janus-kinases-or-pde-4-as-targets","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/topically-applied-small-molecules-janus-kinases-or-pde-4-as-targets\/","title":{"rendered":"Topically Applied &#8220;Small Molecules&#8221;: Janus Kinases or PDE-4 as Targets?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Intracellular target structures have gained importance as therapeutic targets for small-molecule therapeutics in atopic dermatitis (AD), and topical formulation ensures a localized pharmacological effect, thereby promoting a favorable safety profile [1,2]. In some countries, topical Janus kinase (JAK) inhibitors have cleared regulatory hurdles for the treatment of AD\u2014for example, delgocitinib is approved in Japan, and ruxolitinib has recently been approved in the EU in addition to the United States. Among topical phosphodiesterase (PDE)-4 inhibitors, in addition to crisaborol and roflumilast, difamilast has also recently received FDA approval.  <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Ftopically-applied-small-molecules-janus-kinases-or-pde-4-as-targets%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Intracellular target structures have gained importance as therapeutic targets for small-molecule therapeutics in atopic dermatitis (AD), and topical formulation ensures a localized pharmacological effect, thereby promoting a favorable safety profile&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Ftopically-applied-small-molecules-janus-kinases-or-pde-4-as-targets%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":564153,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Atopic Dermatitis in Children and Adults  ","footnotes":"","_members_access_role":[],"_members_access_error":""},"category":[11548,11331,11340,11508,11442,11503],"tags":[12624,94989,100159,80615,80614,100157,68784,100155,100161,100162,73237,80613,15545,12546,100154],"powerkit_post_featured":[],"class_list":["post-564145","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-allergology-and-clinical-immunology","category-dermatology-and-venereology","category-education","category-pharmacology-and-toxicology","category-studies","tag-atopic-dermatitis-en","tag-crisaborol","tag-crisade-control","tag-delgocitinib-en","tag-difamilast-en","tag-integument","tag-janus-kinases","tag-pde-4","tag-qba4-1","tag-qba4-2","tag-roflumilast-en","tag-ruxolitinib-en","tag-small-molecules-en","tag-topical-therapy","tag-true-ad","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-10-02 13:40:10","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":564159,"slug":"petites-molecules-a-usage-topique-les-januskinases-ou-la-pde-4-comme-cibles","post_title":"\u00ab Petites mol\u00e9cules \u00bb \u00e0 usage topique : les januskinases ou la PDE-4 comme cibles ?","href":"https:\/\/medizinonline.com\/fr\/petites-molecules-a-usage-topique-les-januskinases-ou-la-pde-4-comme-cibles\/"},"it_IT":{"locale":"it_IT","id":564165,"slug":"piccole-molecole-per-uso-topico-le-chinasi-janus-o-la-pde-4-come-bersaglio","post_title":"\u00abPiccole molecole\u00bb per uso topico: le chinasi Janus o la PDE-4 come bersaglio?","href":"https:\/\/medizinonline.com\/it\/piccole-molecole-per-uso-topico-le-chinasi-janus-o-la-pde-4-come-bersaglio\/"},"pt_PT":{"locale":"pt_PT","id":564271,"slug":"pequenas-moleculas-de-aplicacao-topica-as-janus-quinases-ou-a-pde-4-como-alvo","post_title":"\u00abPequenas mol\u00e9culas\u00bb de aplica\u00e7\u00e3o t\u00f3pica: as janus-quinases ou a PDE-4 como alvo?","href":"https:\/\/medizinonline.com\/pt-pt\/pequenas-moleculas-de-aplicacao-topica-as-janus-quinases-ou-a-pde-4-como-alvo\/"},"es_ES":{"locale":"es_ES","id":564282,"slug":"moleculas-pequenas-de-aplicacion-topica-las-janusquinasas-o-la-pde-4-como-diana","post_title":"\u00abMol\u00e9culas peque\u00f1as\u00bb de aplicaci\u00f3n t\u00f3pica: \u00bflas janusquinasas o la PDE-4 como diana?","href":"https:\/\/medizinonline.com\/es\/moleculas-pequenas-de-aplicacion-topica-las-janusquinasas-o-la-pde-4-como-diana\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/564145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=564145"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/564145\/revisions"}],"predecessor-version":[{"id":564158,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/564145\/revisions\/564158"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/564153"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=564145"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=564145"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=564145"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=564145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}