{"id":567150,"date":"2026-10-12T12:30:00","date_gmt":"2026-10-12T10:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=567150"},"modified":"2026-09-21T11:03:06","modified_gmt":"2026-09-21T09:03:06","slug":"early-impairment-of-glucagon-counterregulation","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/early-impairment-of-glucagon-counterregulation\/","title":{"rendered":"Early Impairment of Glucagon Counterregulation"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Impaired glucagon-mediated counterregulation is a key factor in severe hypoglycemia in type 1 diabetes (T1D). Although this is well documented in adults, the onset and progression in children and adolescents remain inadequately characterized, as long-term data on pediatric T1D are limited. Metrics derived from CGM have now been identified as non-invasive surrogate markers for impaired counterregulation, which could be used for early risk stratification of hypoglycemia in children with T1D.<\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fearly-impairment-of-glucagon-counterregulation%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Impaired glucagon-mediated counterregulation is a key factor in severe hypoglycemia in type 1 diabetes (T1D). Although this is well documented in adults, the onset and progression in children and adolescents&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fearly-impairment-of-glucagon-counterregulation%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":567153,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Type 1 Diabetes in Childhood  ","footnotes":"","_members_access_role":[],"_members_access_error":""},"category":[11548,11508,11384,11437,11503],"tags":[70313,11655,39999,102295,61468,15809,74262,79972],"powerkit_post_featured":[],"class_list":["post-567150","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-education","category-endocrinology-and-diabetology","category-pediatrics","category-studies","tag-cgm-en-2","tag-diabetes-en","tag-glucagon","tag-glucagon-mediated-counterregulation","tag-hypoglycemias","tag-pediatrics","tag-t1d-en","tag-type-1-diabetes","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-10-20 00:07:00","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":567158,"slug":"alteration-precoce-de-la-contre-regulation-du-glucagon","post_title":"Alt\u00e9ration pr\u00e9coce de la contre-r\u00e9gulation du glucagon","href":"https:\/\/medizinonline.com\/fr\/alteration-precoce-de-la-contre-regulation-du-glucagon\/"},"it_IT":{"locale":"it_IT","id":567167,"slug":"compromissione-precoce-della-controregolazione-del-glucagone","post_title":"Compromissione precoce della controregolazione del glucagone","href":"https:\/\/medizinonline.com\/it\/compromissione-precoce-della-controregolazione-del-glucagone\/"},"pt_PT":{"locale":"pt_PT","id":567176,"slug":"alteracao-precoce-da-contrarregulacao-do-glucagon","post_title":"Altera\u00e7\u00e3o precoce da contrarregula\u00e7\u00e3o do glucagon","href":"https:\/\/medizinonline.com\/pt-pt\/alteracao-precoce-da-contrarregulacao-do-glucagon\/"},"es_ES":{"locale":"es_ES","id":567188,"slug":"alteracion-precoz-de-la-contrarregulacion-del-glucagon","post_title":"Alteraci\u00f3n precoz de la contrarregulaci\u00f3n del glucag\u00f3n","href":"https:\/\/medizinonline.com\/es\/alteracion-precoz-de-la-contrarregulacion-del-glucagon\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/567150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=567150"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/567150\/revisions"}],"predecessor-version":[{"id":567156,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/567150\/revisions\/567156"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/567153"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=567150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=567150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=567150"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=567150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}